Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2210134..2210741 Replicon chromosome
Accession NZ_CP063772
Organism Lysobacter sp. H21R4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag INQ40_RS10090 Protein ID WP_194340328.1
Coordinates 2210134..2210448 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag INQ40_RS10095 Protein ID WP_194340329.1
Coordinates 2210451..2210741 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ40_RS10060 2207254..2207556 - 303 WP_194340322.1 type II toxin-antitoxin system RelE/ParE family toxin -
INQ40_RS10065 2207544..2207801 - 258 WP_194340323.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
INQ40_RS10070 2207922..2208275 + 354 WP_194340324.1 hypothetical protein -
INQ40_RS10075 2208236..2208796 + 561 WP_194340325.1 hypothetical protein -
INQ40_RS10080 2209029..2209526 + 498 WP_194340326.1 pilin -
INQ40_RS10085 2209691..2209987 + 297 WP_194340327.1 hypothetical protein -
INQ40_RS10090 2210134..2210448 + 315 WP_194340328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INQ40_RS10095 2210451..2210741 + 291 WP_194340329.1 transcriptional regulator Antitoxin
INQ40_RS10100 2210984..2211916 + 933 Protein_1965 Fic family protein -
INQ40_RS10105 2211975..2212118 + 144 Protein_1966 XRE family transcriptional regulator -
INQ40_RS10110 2212236..2212373 - 138 Protein_1967 addiction module antidote protein, HigA family -
INQ40_RS10115 2212465..2214195 + 1731 WP_194340330.1 type IV-A pilus assembly ATPase PilB -
INQ40_RS10120 2214290..2214595 + 306 WP_194342515.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2196233..2228294 32061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11634.42 Da        Isoelectric Point: 9.7159

>T178770 WP_194340328.1 NZ_CP063772:2210134-2210448 [Lysobacter sp. H21R4]
MIFIETAVFTRQISEMVTDERYAEFQRLLADSPEAGDVIKGTGGLRKIRLALDNRGKSGGSRVIYYYFVNASQIALLFAY
PKNVASDLTAEQKAVLKQIIAKWS

Download         Length: 315 bp

>T178770 NZ_CP084278:c31495-31214 [Caballeronia grimmiae]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10649.29 Da        Isoelectric Point: 10.4689

>AT178770 WP_194340329.1 NZ_CP063772:2210451-2210741 [Lysobacter sp. H21R4]
MNKNLFAELLESVEQAGEIIRGERAASREFNVDAVDIKKIRAVTGLSQPNFAKILDVDVGTLRNWEQGRRAPTGPARALL
RAIKKDPEHVMRALAV

Download         Length: 291 bp

>AT178770 NZ_CP084278:c31745-31482 [Caballeronia grimmiae]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References