Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 70802..71453 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP063770 | ||
| Organism | Acinetobacter sp. Ac-14 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S3SZA7 |
| Locus tag | IOD65_RS19225 | Protein ID | WP_000269903.1 |
| Coordinates | 70802..71158 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IOD65_RS19230 | Protein ID | WP_001140619.1 |
| Coordinates | 71151..71453 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IOD65_RS19190 | 66285..67025 | + | 741 | WP_005071535.1 | SDR family oxidoreductase | - |
| IOD65_RS19195 | 67098..68096 | + | 999 | WP_005071537.1 | zinc-binding alcohol dehydrogenase family protein | - |
| IOD65_RS19200 | 68116..68400 | + | 285 | WP_005071539.1 | antibiotic biosynthesis monooxygenase | - |
| IOD65_RS19205 | 68576..68746 | + | 171 | Protein_77 | IS3 family transposase | - |
| IOD65_RS19210 | 68744..68839 | + | 96 | Protein_78 | DNA-binding protein | - |
| IOD65_RS19215 | 69247..69609 | + | 363 | Protein_79 | DNA-binding protein | - |
| IOD65_RS19220 | 69960..70277 | + | 318 | WP_000900860.1 | hypothetical protein | - |
| IOD65_RS19225 | 70802..71158 | + | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IOD65_RS19230 | 71151..71453 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| IOD65_RS19235 | 71446..71655 | + | 210 | WP_000069471.1 | hypothetical protein | - |
| IOD65_RS19240 | 71765..71992 | - | 228 | WP_005071544.1 | hypothetical protein | - |
| IOD65_RS19245 | 72750..73295 | - | 546 | Protein_85 | IS5 family transposase | - |
| IOD65_RS19250 | 73223..73611 | - | 389 | Protein_86 | AAA family ATPase | - |
| IOD65_RS19255 | 73797..74117 | + | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| IOD65_RS19260 | 74394..74582 | + | 189 | WP_000033474.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IOD65_RS19265 | 74569..74856 | + | 288 | WP_001258992.1 | helix-turn-helix transcriptional regulator | - |
| IOD65_RS19270 | 75140..75364 | - | 225 | WP_005071551.1 | hypothetical protein | - |
| IOD65_RS19275 | 75388..75945 | - | 558 | Protein_91 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..117968 | 117968 | |
| - | flank | IS/Tn | - | - | 72750..72995 | 245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13486.45 Da Isoelectric Point: 7.1645
>T178765 WP_000269903.1 NZ_CP063770:70802-71158 [Acinetobacter sp. Ac-14]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T178765 NZ_CP084260:638702-638881 [Caballeronia sp. SL2Y3]
ATGAAGTACAGCGAATTCAAAAGGTGGCTGCGCCAGCAAGGAGCTGAGTTCAAGCCGGCAAAAGGAAGCCGTTTTCGCGT
GACCTTGCATGGAAGAACAACGATTTTCCCCGACCATGGAAGCAGGGAAATCGGTACCAAGCTAGTCGAACAGATCAAGA
AACAACTGGGATTGAAGTGA
ATGAAGTACAGCGAATTCAAAAGGTGGCTGCGCCAGCAAGGAGCTGAGTTCAAGCCGGCAAAAGGAAGCCGTTTTCGCGT
GACCTTGCATGGAAGAACAACGATTTTCCCCGACCATGGAAGCAGGGAAATCGGTACCAAGCTAGTCGAACAGATCAAGA
AACAACTGGGATTGAAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT178765 WP_001140619.1 NZ_CP063770:71151-71453 [Acinetobacter sp. Ac-14]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT178765 NZ_CP084260:638917-639336 [Caballeronia sp. SL2Y3]
ATGTTGTCTTATCCAGTCAACCTGGAGCTCGATACCAACAACAGCTACCTGGTGACGTTCCCCGACATTCCGGAAGCGGT
GTCGGTAGGCGACGACGAACAGGAGGCGCTTCTGAATGCGCTGGATGCGCTCGAAAGCGCCATCGAAATTTACTTCGATG
AGAAACGCGAATTGCCGCCTCCGTCGAAGCCGCGCAAGGGGCAGGCCGTCGTTACGTTGCCGGCGCTCGTCGTCTCGAAA
GTTCTATTGGCTAACGAAATGGTGCGGCAAGGCGTGCGAAAGTCCGAGCTTGCGCGTCGGCTCAACGTTCACATGCCGCA
GGTGGACCGGCTGCTGAATCCGCGTCATCCGTCAAAACTCGACGCTATTGAAGCCGCATTGAAGTCGCTGGGCAAGCGCC
TCAGCATTTCTCTCGCGTAG
ATGTTGTCTTATCCAGTCAACCTGGAGCTCGATACCAACAACAGCTACCTGGTGACGTTCCCCGACATTCCGGAAGCGGT
GTCGGTAGGCGACGACGAACAGGAGGCGCTTCTGAATGCGCTGGATGCGCTCGAAAGCGCCATCGAAATTTACTTCGATG
AGAAACGCGAATTGCCGCCTCCGTCGAAGCCGCGCAAGGGGCAGGCCGTCGTTACGTTGCCGGCGCTCGTCGTCTCGAAA
GTTCTATTGGCTAACGAAATGGTGCGGCAAGGCGTGCGAAAGTCCGAGCTTGCGCGTCGGCTCAACGTTCACATGCCGCA
GGTGGACCGGCTGCTGAATCCGCGTCATCCGTCAAAACTCGACGCTATTGAAGCCGCATTGAAGTCGCTGGGCAAGCGCC
TCAGCATTTCTCTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|