Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 70802..71453 Replicon plasmid unnamed1
Accession NZ_CP063770
Organism Acinetobacter sp. Ac-14

Toxin (Protein)


Gene name higB Uniprot ID S3SZA7
Locus tag IOD65_RS19225 Protein ID WP_000269903.1
Coordinates 70802..71158 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IOD65_RS19230 Protein ID WP_001140619.1
Coordinates 71151..71453 (+) Length 101 a.a.

Genomic Context

IOD65_RS19190IOD65_RS19195IOD65_RS19200IOD65_RS19205IOD65_RS19210IOD65_RS19215IOD65_RS19220IOD65_RS19225IOD65_RS19230IOD65_RS19235IOD65_RS19255IOD65_RS19260IOD65_RS19265IOD65_RS19240IOD65_RS19245IOD65_RS19250IOD65_RS19270IOD65_RS19275
Location: 66285..67025 (741 bp)
Type: Others
Protein ID: WP_005071535.1
Location: 67098..68096 (999 bp)
Type: Others
Protein ID: WP_005071537.1
Location: 68116..68400 (285 bp)
Type: Others
Protein ID: WP_005071539.1
Location: 68576..68746 (171 bp)
Type: Others
Protein ID: Protein_77
Location: 68744..68839 (96 bp)
Type: Others
Protein ID: Protein_78
Location: 69247..69609 (363 bp)
Type: Others
Protein ID: Protein_79
Location: 69960..70277 (318 bp)
Type: Others
Protein ID: WP_000900860.1
Location: 70802..71158 (357 bp)
Type: Toxin
Protein ID: WP_000269903.1
Location: 71151..71453 (303 bp)
Type: Antitoxin
Protein ID: WP_001140619.1
Location: 71446..71655 (210 bp)
Type: Others
Protein ID: WP_000069471.1
Location: 73797..74117 (321 bp)
Type: Others
Protein ID: WP_002123990.1
Location: 74394..74582 (189 bp)
Type: Others
Protein ID: WP_000033474.1
Location: 74569..74856 (288 bp)
Type: Others
Protein ID: WP_001258992.1
Location: 71765..71992 (228 bp)
Type: Others
Protein ID: WP_005071544.1
Location: 72750..73295 (546 bp)
Type: Others
Protein ID: Protein_85
Location: 73223..73611 (389 bp)
Type: Others
Protein ID: Protein_86
Location: 75140..75364 (225 bp)
Type: Others
Protein ID: WP_005071551.1
Location: 75388..75945 (558 bp)
Type: Others
Protein ID: Protein_91
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IOD65_RS1919066285..67025+741WP_005071535.1SDR family oxidoreductase-
IOD65_RS1919567098..68096+999WP_005071537.1zinc-binding alcohol dehydrogenase family protein-
IOD65_RS1920068116..68400+285WP_005071539.1antibiotic biosynthesis monooxygenase-
IOD65_RS1920568576..68746+171Protein_77IS3 family transposase-
IOD65_RS1921068744..68839+96Protein_78DNA-binding protein-
IOD65_RS1921569247..69609+363Protein_79DNA-binding protein-
IOD65_RS1922069960..70277+318WP_000900860.1hypothetical protein-
IOD65_RS1922570802..71158+357WP_000269903.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IOD65_RS1923071151..71453+303WP_001140619.1XRE family transcriptional regulatorAntitoxin
IOD65_RS1923571446..71655+210WP_000069471.1hypothetical protein-
IOD65_RS1924071765..71992-228WP_005071544.1hypothetical protein-
IOD65_RS1924572750..73295-546Protein_85IS5 family transposase-
IOD65_RS1925073223..73611-389Protein_86AAA family ATPase-
IOD65_RS1925573797..74117+321WP_002123990.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IOD65_RS1926074394..74582+189WP_000033474.1type II toxin-antitoxin system RelE/ParE family toxin-
IOD65_RS1926574569..74856+288WP_001258992.1helix-turn-helix transcriptional regulator-
IOD65_RS1927075140..75364-225WP_005071551.1hypothetical protein-
IOD65_RS1927575388..75945-558Protein_91hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..117968117968
-flankIS/Tn--72750..72995245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13486.45 Da        Isoelectric Point: 7.1645

>T178765 WP_000269903.1 NZ_CP063770:70802-71158 [Acinetobacter sp. Ac-14]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

>T178765 NZ_CP084260:638702-638881 [Caballeronia sp. SL2Y3]
ATGAAGTACAGCGAATTCAAAAGGTGGCTGCGCCAGCAAGGAGCTGAGTTCAAGCCGGCAAAAGGAAGCCGTTTTCGCGT
GACCTTGCATGGAAGAACAACGATTTTCCCCGACCATGGAAGCAGGGAAATCGGTACCAAGCTAGTCGAACAGATCAAGA
AACAACTGGGATTGAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT178765 WP_001140619.1 NZ_CP063770:71151-71453 [Acinetobacter sp. Ac-14]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT178765 NZ_CP084260:638917-639336 [Caballeronia sp. SL2Y3]
ATGTTGTCTTATCCAGTCAACCTGGAGCTCGATACCAACAACAGCTACCTGGTGACGTTCCCCGACATTCCGGAAGCGGT
GTCGGTAGGCGACGACGAACAGGAGGCGCTTCTGAATGCGCTGGATGCGCTCGAAAGCGCCATCGAAATTTACTTCGATG
AGAAACGCGAATTGCCGCCTCCGTCGAAGCCGCGCAAGGGGCAGGCCGTCGTTACGTTGCCGGCGCTCGTCGTCTCGAAA
GTTCTATTGGCTAACGAAATGGTGCGGCAAGGCGTGCGAAAGTCCGAGCTTGCGCGTCGGCTCAACGTTCACATGCCGCA
GGTGGACCGGCTGCTGAATCCGCGTCATCCGTCAAAACTCGACGCTATTGAAGCCGCATTGAAGTCGCTGGGCAAGCGCC
TCAGCATTTCTCTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A836MG83

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References