Detailed information of TA system TA178705

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2568721..2569000
• Replicon: chromosome
• Accession: NZ_CP063745
• Organism: Staphylococcus aureus strain NAS_AN_212

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF732_RS12475
• Protein ID: WP_001802298.1
• Coordinates: 2568721..2568825 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2568821..2569000 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF732_RS12450	2564620..2565228	+	609	WP_000101715.1	TIR domain-containing protein	-
IF732_RS12455	2565518..2566300	+	783	WP_000908191.1	ABC transporter ATP-binding protein	-
IF732_RS12460	2566368..2567225	+	858	WP_000370942.1	HAD family hydrolase	-
IF732_RS12465	2567355..2567447	-	93	WP_000220902.1	hypothetical protein	-
IF732_RS12470	2567883..2568041	-	159	WP_001792784.1	hypothetical protein	-
IF732_RS12475	2568721..2568825	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2568821..2569000	-	180	-	-	Antitoxin
IF732_RS12485	2569323..2570414	-	1092	WP_000495673.1	hypothetical protein	-
IF732_RS12490	2570680..2571660	-	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
IF732_RS12495	2571662..2571982	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF732_RS12500	2572134..2572799	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T178705 WP_001802298.1 NZ_CP063745:2568721-2568825 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T178705 NZ_CP084209:c4034984-4034634 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT178705 NZ_CP063745:c2569000-2568821 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin