Detailed information of TA system TA178702

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2273004..2273188
• Replicon: chromosome
• Accession: NZ_CP063745
• Organism: Staphylococcus aureus strain NAS_AN_212

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF732_RS10925
• Protein ID: WP_000482647.1
• Coordinates: 2273004..2273111 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2273128..2273188 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF732_RS10900	2268361..2268834	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF732_RS10905	2268957..2270168	-	1212	WP_001191974.1	multidrug effflux MFS transporter	-
IF732_RS10910	2270356..2271015	-	660	WP_000831300.1	hypothetical protein	-
IF732_RS10915	2271075..2272217	-	1143	WP_240104845.1	glycerate kinase	-
IF732_RS10920	2272484..2272870	+	387	WP_000779355.1	flippase GtxA	-
IF732_RS10925	2273004..2273111	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2273128..2273188	-	61	-	-	Antitoxin
IF732_RS10930	2273815..2275578	+	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
IF732_RS10935	2275603..2277336	+	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
IF732_RS10940	2277567..2277734	+	168	WP_001798790.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T178702 WP_000482647.1 NZ_CP063745:2273004-2273111 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T178702 NZ_CP084209:3595010-3595288 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT178702 NZ_CP063745:c2273188-2273128 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin