Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2581053..2581633 Replicon chromosome
Accession NZ_CP063659
Organism Synechocystis sp. PCC 7339

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag IQE94_RS12270 Protein ID WP_223342044.1
Coordinates 2581340..2581633 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IQE94_RS12265 Protein ID WP_194019399.1
Coordinates 2581053..2581334 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE94_RS12245 (IQE94_12115) 2576415..2578013 + 1599 WP_190596915.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
IQE94_RS12250 (IQE94_12120) 2578077..2578310 + 234 WP_010873234.1 preprotein translocase subunit SecG -
IQE94_RS12255 (IQE94_12125) 2578437..2579222 + 786 WP_223342042.1 hypothetical protein -
IQE94_RS12260 (IQE94_12130) 2579383..2580693 - 1311 WP_223342043.1 dihydrolipoamide acetyltransferase family protein -
IQE94_RS12265 (IQE94_12135) 2581053..2581334 - 282 WP_194019399.1 HigA family addiction module antitoxin Antitoxin
IQE94_RS12270 (IQE94_12140) 2581340..2581633 - 294 WP_223342044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQE94_RS12275 (IQE94_12150) 2581795..2583456 - 1662 Protein_2432 bifunctional serine/threonine-protein kinase/formylglycine-generating enzyme family protein -
IQE94_RS12280 (IQE94_12155) 2583638..2584276 + 639 WP_190596904.1 DUF3318 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(21-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11100.53 Da        Isoelectric Point: 9.7333

>T178683 WP_223342044.1 NZ_CP063659:c2581633-2581340 [Synechocystis sp. PCC 7339]
MITSFGNQATADLFNGINSRNSRRIPSEITQKALNKLDILNAVEKLEELNSPPGNRLEALKGNLKGFYSIRINNQWRIIF
QWQNGNVSQVQIIDYHD

Download         Length: 294 bp

>T178683 NZ_CP084209:651314-651628 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10764.49 Da        Isoelectric Point: 4.6828

>AT178683 WP_194019399.1 NZ_CP063659:c2581334-2581053 [Synechocystis sp. PCC 7339]
MLPTNRLPTHPGIILLEEFLEPMNITQETLATYLNISVKQINEIIQEKNEITPKIAWLLAQAFDTTPQFWMNLQTNYDLA
LNKPQETKQAIKV

Download         Length: 282 bp

>AT178683 NZ_CP084209:651625-652041 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References