178624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2732406..2733724 Replicon chromosome
Accession NZ_CP063515
Organism Escherichia coli strain EH01-18-04-A

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag IQS17_RS13410 Protein ID WP_001262467.1
Coordinates 2732406..2733413 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag IQS17_RS13415 Protein ID WP_001312177.1
Coordinates 2733413..2733724 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS17_RS13380 2727616..2727807 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
IQS17_RS13385 2727804..2729483 + 1680 Protein_2625 cellulose biosynthesis protein BcsG -
IQS17_RS13390 2729569..2729676 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
IQS17_RS13395 2730052..2730159 - 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
IQS17_RS13400 2730535..2730642 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
IQS17_RS13405 2731118..2732389 + 1272 WP_001545666.1 amino acid permease -
IQS17_RS13410 2732406..2733413 - 1008 WP_001262467.1 HipA domain-containing protein Toxin
IQS17_RS13415 2733413..2733724 - 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
IQS17_RS13420 2733709..2734032 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
IQS17_RS13425 2734257..2735270 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
IQS17_RS13430 2735267..2736250 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
IQS17_RS13435 2736261..2737163 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
IQS17_RS13440 2737173..2738192 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T178624 WP_001262467.1 NZ_CP063515:c2733413-2732406 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T178624 NZ_CP084204:5476655-5477026 [Streptomyces tanashiensis]
GTGACGCACTACCTCACCCTCCCCGAGCTCCTGAACCTCGCAGAACGACTCGGGGCGAACGAGGTGCGCGACTACGGTCT
CCTCGACTCCGCTCTGGCGCGCCCGCAGTCGAGCGTGTTCGGGCAGGACGCCTACCCGGACGTCTGGCAGAAGGCCGCGG
CGCTCATGGAATCACTCTCCCGTAATCACGGGCTGGTGGACGGGAACAAGCGCATCGCCTGGTACGCGACCTGGGTCTTC
CTGCACATGAACGGGCACCCGCTCGACCCCGGCTTCGACGTCGACGAAGCCGAGTCGTTCGTCCTGGACGTCTGCCAGGG
TGCCCTCGACGTCCCGAAGATCGCCGCGCAGCTACCGAGGTTCGCGCGCTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT178624 WP_001312177.1 NZ_CP063515:c2733724-2733413 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT178624 NZ_CP084204:5476461-5476658 [Streptomyces tanashiensis]
ATGGCTGGTCTCAATGTCAGGTTCACCGAGGAAGAGCTGGACGCCCTGCGTGAGCGGGCCGAGGCGGAGGGACGCAGCAT
GCAGTCCTTCGCTCACGACGCCGTGATCCGTGCCATAAACGAGCACTCACGCCTCTTCAACGAGGCCGCCGAGCATGTGC
TGAAGGCCAGCGAGGAGCTGAACCGGAGGCTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References