Detailed information of TA system TA178622

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2730535..2730757
• Replicon: chromosome
• Accession: NZ_CP063515
• Organism: Escherichia coli strain EH01-18-04-A

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: IQS17_RS13400
• Protein ID: WP_001295224.1
• Coordinates: 2730535..2730642 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2730691..2730757 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS17_RS13370	2725587..2725775	-	189	WP_001063314.1	YhjR family protein	-
IQS17_RS13375	2726048..2727619	+	1572	WP_001204941.1	cellulose biosynthesis protein BcsE	-
IQS17_RS13380	2727616..2727807	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
IQS17_RS13385	2727804..2729483	+	1680	Protein_2625	cellulose biosynthesis protein BcsG	-
IQS17_RS13390	2729569..2729676	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
IQS17_RS13395	2730052..2730159	-	108	WP_000170748.1	type I toxin-antitoxin system toxin Ldr family protein	-
IQS17_RS13400	2730535..2730642	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2730691..2730757	+	67	-	-	Antitoxin
IQS17_RS13405	2731118..2732389	+	1272	WP_001545666.1	amino acid permease	-
IQS17_RS13410	2732406..2733413	-	1008	WP_001262467.1	HipA domain-containing protein	-
IQS17_RS13415	2733413..2733724	-	312	WP_001312177.1	HipA N-terminal domain-containing protein	-
IQS17_RS13420	2733709..2734032	-	324	WP_000563102.1	helix-turn-helix transcriptional regulator	-
IQS17_RS13425	2734257..2735270	-	1014	WP_000103572.1	dipeptide ABC transporter ATP-binding subunit DppF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T178622 WP_001295224.1 NZ_CP063515:c2730642-2730535 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T178622 NZ_CP084198:551367-551837 [Pantoea agglomerans]
TTGATTCTCTACAGGCTGACCAAGACAAAGTATCTTTCGACAGCCTGGACGGGATTTGGCGCAAAAGAGGCGGGCGGCCG
CTGGAACAGCATCGGCATCTCCATGGTTTATGTTTCTGAAACAGCATCGCTGACTTTGCTGGAAACACTGGTCCATCTGC
ACTCAGCACACATCCTGGACGCGTTCACACTTCTGCGCATCGATGTTCCCGATGCGCTGATTCAGACCGCTGATATCACT
GAGTTGCCTGCAAACTGGGCCGATGAAGACGCACCGGCAGAACTGGCTGACTATGGAGACGCCTGGTGCTCTGCCTGCGA
TGCGGTTGCGTTGCGTGTTCCCAGTGCTCTCTCCCCTGTAGAATATAACTATCTGTTAAATCCTGAACACCCCGATTTCT
TCCGTATAGTTCAACAGGCTGAGGCTATTCCGTTCCGGTTTGATCGTCGGCTGAAACCGGATCGTAAATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT178622 NZ_CP063515:2730691-2730757 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin