Detailed information of TA system TA178611

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1518527..1518791
• Replicon: chromosome
• Accession: NZ_CP063515
• Organism: Escherichia coli strain EH01-18-04-A

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: IQS17_RS07560
• Protein ID: WP_001387489.1
• Coordinates: 1518527..1518679 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	1518731..1518791 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS17_RS07540	1514731..1515723	-	993	WP_001546061.1	hypothetical protein	-
IQS17_RS07545	1515779..1517386	-	1608	Protein_1484	intimin-like inverse autotransporter SinH	-
IQS17_RS07550	1517608..1517904	-	297	WP_011264046.1	hypothetical protein	-
IQS17_RS07555	1518204..1518455	+	252	WP_001291964.1	hypothetical protein	-
IQS17_RS07560	1518527..1518679	-	153	WP_001387489.1	Hok/Gef family protein	Toxin
-	1518731..1518791	+	61	NuclAT_14	-	Antitoxin
-	1518731..1518791	+	61	NuclAT_14	-	Antitoxin
-	1518731..1518791	+	61	NuclAT_14	-	Antitoxin
-	1518731..1518791	+	61	NuclAT_14	-	Antitoxin
IQS17_RS07565	1518994..1520085	+	1092	WP_000426061.1	hypothetical protein	-
-	1520155..1520212	+	58	NuclAT_15	-	-
-	1520155..1520212	+	58	NuclAT_15	-	-
-	1520155..1520212	+	58	NuclAT_15	-	-
-	1520155..1520212	+	58	NuclAT_15	-	-
IQS17_RS07570	1520392..1521600	+	1209	WP_001703845.1	IncI1-type conjugal transfer protein TrbA	-
IQS17_RS07575	1521619..1522689	+	1071	WP_012783932.1	IncI1-type conjugal transfer protein TrbB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T178611 WP_001387489.1 NZ_CP063515:c1518679-1518527 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T178611 NZ_CP084195:54243-54641 [Salmonella sp. A39]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT178611 NZ_CP063515:1518731-1518791 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin