Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1769445..1770172 Replicon chromosome
Accession NZ_CP063511
Organism Escherichia coli strain EH08-18-36

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag IQS18_RS08560 Protein ID WP_000550189.1
Coordinates 1769445..1769759 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IQS18_RS08565 Protein ID WP_000560255.1
Coordinates 1769756..1770172 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS18_RS08540 1765602..1766588 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
IQS18_RS08545 1766667..1767359 - 693 WP_203024066.1 vancomycin high temperature exclusion protein -
IQS18_RS08550 1767436..1767939 - 504 WP_001300832.1 M48 family metallopeptidase -
IQS18_RS08555 1768025..1769161 + 1137 WP_032266667.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
IQS18_RS08560 1769445..1769759 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
IQS18_RS08565 1769756..1770172 + 417 WP_000560255.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
IQS18_RS08570 1770217..1772235 - 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
IQS18_RS08575 1772661..1775012 - 2352 WP_053270544.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T178578 WP_000550189.1 NZ_CP063511:1769445-1769759 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T178578 NZ_CP084115:2663855-2664319 [Cobetia amphilecti]
ATGACTGTGGTGCGCGGTTATCGGCTCGTTAAGCGGAAGTGGCTAAAGACAGCCTTTGATGGGGAAGGGGCTCGGCTGTA
CGGCGGGCGCTGGAACAGCAAAGGTAAGGCCTGTGTGTACCTCGCGAGCACAGAGTCATTGGCCATGCTCGAGGTGATGG
TTCATCTGGAAGACAACCAACTGCTGAAGGAGTATGCGCTCCTGGAGGTGACATTCCGACAAGAGGTGCTAATGCAGCTC
CCGGAGGACGTTCTGCCAGCAGATTGGCGAGCTGAGCCGGCGCCACCTTCCACAGCCGAGATCGGTGACGACTGGCTTGA
GGGACAGTCGAGCCTAGTTCTGGCGGTTCCGAGTGTGGTCGCGCCCCGAGAAACGAACTACCTCGTTAATCCAGAGCACC
CCGATTTTCTGGCGCTGGCCCAGAATGCCGAAGAGGTAGATTTCACTCCAGATCGTCGACTGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14951.41 Da        Isoelectric Point: 4.5577

>AT178578 WP_000560255.1 NZ_CP063511:1769756-1770172 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT178578 NZ_CP084115:2663406-2663858 [Cobetia amphilecti]
ATGCAAGCCGCTATCAAAGAGTATCGCCCAAAACCAACCGCTCGGAAGGACGACTTCTGGAGGGCTCTGGGTCTCCCCTC
GCGTGGAGCCAAACTGCATGAAGCGCTGAGTGCCGGCATCTCGTACAAAGTCTATACCAAGCTCACCGAGGCCTCCGGGC
TTGAGAGCAAGGAGCTGGCACGGTATGTGGTCATTCCTCCGGCAACCCTGAAGCGTCGTGCCGATACTGGCTACTTCAAA
CCTGCCGAGGGCGATCGGCTTTACCGTTTCGCTGAGGTGTACAAGAGCGCGATGGACTTGTTCGAAGGCGACAAGGCGAA
GGCGAAAGAATGGTTGCTCAGCCCCGTGCGTGGGCTGGGGGGCCGTCGACCGGTCGAGATGGTGGCTACCACTGCTGGCG
CTGAAGCCGTTCTAGATCTGATCGGCCGGCTTGAGCATGGCGTCTTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References