Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4214526..4215219 Replicon chromosome
Accession NZ_CP063499
Organism Escherichia coli strain EH10-18-47

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IQS20_RS20265 Protein ID WP_000415584.1
Coordinates 4214526..4214822 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IQS20_RS20270 Protein ID WP_000650107.1
Coordinates 4214824..4215219 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS20_RS20230 4209614..4209928 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IQS20_RS20235 4209959..4210540 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IQS20_RS20240 4210859..4211191 + 333 WP_000917684.1 DUF2645 family protein -
IQS20_RS20245 4211237..4212586 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IQS20_RS20250 4212583..4213242 - 660 WP_001221493.1 two-component system response regulator QseB -
IQS20_RS20255 4213394..4213786 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IQS20_RS20260 4213839..4214321 + 483 WP_000183505.1 transcriptional regulator -
IQS20_RS20265 4214526..4214822 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IQS20_RS20270 4214824..4215219 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IQS20_RS20275 4215352..4216959 + 1608 WP_096282557.1 ABC transporter substrate-binding protein -
IQS20_RS20280 4217097..4219355 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178531 WP_000415584.1 NZ_CP063499:4214526-4214822 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178531 NZ_CP084096:c2624417-2624310 [Escherichia coli O78]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178531 WP_000650107.1 NZ_CP063499:4214824-4215219 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178531 NZ_CP084096:2624470-2624531 [Escherichia coli O78]
TGGTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References