Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2562792..2563485 Replicon chromosome
Accession NZ_CP063487
Organism Escherichia coli strain EF7-18-51

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IQS15_RS12330 Protein ID WP_000415584.1
Coordinates 2562792..2563088 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IQS15_RS12335 Protein ID WP_000650107.1
Coordinates 2563090..2563485 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS15_RS12295 2557880..2558194 - 315 WP_072711540.1 antibiotic biosynthesis monooxygenase -
IQS15_RS12300 2558225..2558806 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IQS15_RS12305 2559125..2559457 + 333 WP_000917684.1 DUF2645 family protein -
IQS15_RS12310 2559503..2560852 - 1350 WP_001618857.1 two-component system sensor histidine kinase QseC -
IQS15_RS12315 2560849..2561508 - 660 WP_001221493.1 two-component system response regulator QseB -
IQS15_RS12320 2561660..2562052 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IQS15_RS12325 2562105..2562587 + 483 WP_000183505.1 transcriptional regulator -
IQS15_RS12330 2562792..2563088 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IQS15_RS12335 2563090..2563485 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IQS15_RS12340 2563618..2565225 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IQS15_RS12345 2565363..2567621 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178448 WP_000415584.1 NZ_CP063487:2562792-2563088 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178448 NZ_CP084026:1656414-1656668 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178448 WP_000650107.1 NZ_CP063487:2563090-2563485 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178448 NZ_CP084026:1656166-1656417 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References