Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3807228..3807921 Replicon chromosome
Accession NZ_CP063473
Organism Escherichia coli strain EM18-18-42

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IQS24_RS18375 Protein ID WP_000415584.1
Coordinates 3807625..3807921 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IQS24_RS18370 Protein ID WP_000650107.1
Coordinates 3807228..3807623 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS24_RS18360 3803092..3805350 - 2259 WP_096954228.1 DNA topoisomerase IV subunit A -
IQS24_RS18365 3805488..3807095 - 1608 WP_205595483.1 ABC transporter substrate-binding protein -
IQS24_RS18370 3807228..3807623 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IQS24_RS18375 3807625..3807921 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IQS24_RS18380 3808126..3808608 - 483 WP_000183505.1 transcriptional regulator -
IQS24_RS18385 3808661..3809053 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IQS24_RS18390 3809205..3809864 + 660 WP_001221493.1 two-component system response regulator QseB -
IQS24_RS18395 3809861..3811210 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IQS24_RS18400 3811256..3811588 - 333 WP_000917684.1 DUF2645 family protein -
IQS24_RS18405 3811907..3812488 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IQS24_RS18410 3812519..3812833 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178349 WP_000415584.1 NZ_CP063473:c3807921-3807625 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178349 NZ_CP083952:3014614-3015090 [Mesorhizobium sp. B2-1-8]
ATGCCGTCGGCGCCCACGCCGCTGGCCGAAGACCACGATCTCGAACTTTTCCAAAGCGGAACAGAAAGCCTCGACCAATG
GCTTCGCCGTCGGGCACGGGCCAACCAGGTCAGTGGCGCATCACGTACTTATGTGATGGCGGAAGGCACACGCGTTGTCG
GCTACTATTGCTTGTCTTCGGGCGGGCTTGATCTGGCGGAAGCGCCCGGCATTATTCGCCGCAACATGCCAGATCCCATT
CCAATGGTTGTGCTCGGACGTCTCGCGGTGGATGCAAGCTGGCAAGGGAAAGGGCTAGGCGCTGCGCTTCTGCAAGACGC
CGTCCTGCGCTCCAGTCAAGCCGCGACGATCCTCAGGATTCGCGGAATTTTTGTTCACGCCATATCGGATGAAGCGAAAG
CCTTTTACGAGCACTACGGCTTTGCGGCTTCCCCGAAAAATCCCATGATCTTGTTGTTGTCGTTGAAAGGCCAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178349 WP_000650107.1 NZ_CP063473:c3807623-3807228 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178349 NZ_CP083952:3014333-3014614 [Mesorhizobium sp. B2-1-8]
ATGGCGAAAGCCGCACCCGAAACCCATGCCAAGCCTGTCAATCTGCGCATCCGAGAGGACGTACGCATACTGATTGACCG
TGCCGCAAAGATACGCGGGAAAACCCGCTCTGACTTCATGATCGACGTCGCTTATCGTGCGGCCGAGGATACGCTGCTCG
ACCAAACATTGATCAAGGTGGATCCCGAGAGTTACCGGCATTATCTCGACATCCTCGATGAACCGCCAAGCGGGGAAGGT
TTTGCACGCCTTATGAACGTGCCCAGGCCGTGGCGGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References