Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4051146..4051839 Replicon chromosome
Accession NZ_CP063467
Organism Escherichia coli strain EM20-18-50

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IQS25_RS19465 Protein ID WP_000415584.1
Coordinates 4051146..4051442 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IQS25_RS19470 Protein ID WP_000650107.1
Coordinates 4051444..4051839 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS25_RS19430 4046234..4046548 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IQS25_RS19435 4046579..4047160 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IQS25_RS19440 4047479..4047811 + 333 WP_087898735.1 DUF2645 family protein -
IQS25_RS19445 4047857..4049206 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IQS25_RS19450 4049203..4049862 - 660 WP_001221493.1 two-component system response regulator QseB -
IQS25_RS19455 4050014..4050406 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IQS25_RS19460 4050459..4050941 + 483 WP_203139389.1 GyrI-like domain-containing protein -
IQS25_RS19465 4051146..4051442 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IQS25_RS19470 4051444..4051839 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IQS25_RS19475 4051972..4053579 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IQS25_RS19480 4053717..4055975 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178325 WP_000415584.1 NZ_CP063467:4051146-4051442 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178325 NZ_CP083938:c2798057-2797671 [Comamonas thiooxydans]
ATGCCGGTGTCCGTTCTAGTCGATACATCGGTGTGGGTGAGGCATTTTCGGGAGGCCGACATTCACCTGCAGGAGCTCCT
GTTGCAAGACAGCGTGCTGATGCATCCCATGGTGCATGCAGAGTTGGCCTGCGGCACGCCGCCAGCGCCGCGTGCCGATA
CGCTCGCAGCCCTGGCCATGCTGCGGCCGAGCCAGGAAGCTTCAATTCCCGAGACTTTGGCCTTCCTTGAGAAGAACAAG
CTATTCGGTAAGGGCTGCGGCTTGGTCGATCTATCGCTGCTCGCCTCGACGCTAATCACACCAGGCGCTTTGCTTTGGAC
TGCAGATCGACGCCTTGCTGAGTTGGCCGCTCAGCTTGGCGTGGCCTATGCCATACCAACGCATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178325 WP_000650107.1 NZ_CP063467:4051444-4051839 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178325 NZ_CP083938:c2798272-2798057 [Comamonas thiooxydans]
ATGAGATCGACCTTTACGATCGACGACGAAGTCGTGAACCGTGCCCGCGCTGTTGCAGCGCCCGGTATTGCTGTGCCTGA
ACTGGTACGCCTGGCACTTGAGACCTTCACTCGCGTCGAGGCAGGCAAGCGCTTGGCTGCCCTGGGCGGAAGCGCGCCAG
ACATGCCTGACGTGCCACGCCGTGGCAGCGCGGCAGAGGCAGAAGGCTCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References