178278

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2047692..2048385 Replicon chromosome
Accession NZ_CP063459
Organism Escherichia coli strain EM22-18-53

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IQS26_RS09825 Protein ID WP_000415584.1
Coordinates 2048089..2048385 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IQS26_RS09820 Protein ID WP_000650107.1
Coordinates 2047692..2048087 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS26_RS09810 2043556..2045814 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
IQS26_RS09815 2045952..2047559 - 1608 WP_001701096.1 ABC transporter substrate-binding protein -
IQS26_RS09820 2047692..2048087 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IQS26_RS09825 2048089..2048385 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IQS26_RS09830 2048590..2049072 - 483 WP_000183494.1 transcriptional regulator -
IQS26_RS09835 2049125..2049517 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IQS26_RS09840 2049669..2050328 + 660 WP_001221491.1 two-component system response regulator QseB -
IQS26_RS09845 2050325..2051674 + 1350 WP_000673406.1 two-component system sensor histidine kinase QseC -
IQS26_RS09850 2051784..2052365 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IQS26_RS09855 2052396..2052710 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178278 WP_000415584.1 NZ_CP063459:c2048385-2048089 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178278 NZ_CP083902:31855-32184 [Zymomonas mobilis]
GTGAGTGTCAAAGTAACGACTGTCTGGGTTCCTGTCTGGCTTGAGTTTGATCCGCAGGCGGGCAGGGAGCAGGCTGGGCA
CCGACCTGCTGTTGTGCTGAGTCCTGTCAGCTATAATGCTAAAGCTGGAATGATGCTGTGCTGTCCGACAACGACCAAGA
TCAAAGGCTATCCCTTTGAAGTGGCTCTGACTGGAAAAACTGCCAGTGTGGTTTTGTCAGATCAGGTCAGAAGTCTGGAT
TGGCGCGTGAGAAAGACAAAGCTTAAAGATAAAGTTTTGCCAAAAGAGCTTGAGGCAATTCGGCAGCGCATTAGATTGCT
GGTCGGGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178278 WP_000650107.1 NZ_CP063459:c2048087-2047692 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178278 NZ_CP083902:31616-31858 [Zymomonas mobilis]
ATGCAGGGCGTTGTCAGGAAATGGGGGAACAGTGCAGCCATTCGTCTTCCTGTCGGTGTGCTTGAAGCCGTCGGTCTGAA
GATCGATCAGGCCGTCGATGTGCGAGAAGAAGATGGGCGGATCATCATAGAGCCAGTCAGAGCAGTTCCTCTCAAACTGG
AAGAATTAGTGTCAGGTATTACGGTCGAGAACCGCCATGATGAAATGGACTTTGGTTCATCTGTTGGTTGTGAAAGCTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References