Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1654722..1655521 Replicon chromosome
Accession NZ_CP063459
Organism Escherichia coli strain EM22-18-53

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag IQS26_RS07880 Protein ID WP_000347251.1
Coordinates 1654722..1655186 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IQS26_RS07885 Protein ID WP_001307405.1
Coordinates 1655186..1655521 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS26_RS07850 1649723..1650157 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IQS26_RS07855 1650175..1651053 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IQS26_RS07860 1651043..1651822 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IQS26_RS07865 1651833..1652306 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
IQS26_RS07870 1652329..1653609 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
IQS26_RS07875 1653858..1654667 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IQS26_RS07880 1654722..1655186 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IQS26_RS07885 1655186..1655521 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IQS26_RS07890 1655670..1657241 - 1572 WP_048943282.1 galactarate dehydratase -
IQS26_RS07895 1657616..1658950 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
IQS26_RS07900 1658966..1659736 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T178276 WP_000347251.1 NZ_CP063459:c1655186-1654722 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T178276 NZ_CP083901:c19414-19130 [Zymomonas mobilis]
ATGGCTTGGAAAATTGAATTCGATCCAGCCGCGCAAAAAGAGTTGAAAAAATTAGGAACACAGCCAGCTAAGCGGATCTT
AAGATTTTTATCTGAACGATTGGCCTTGGCTGATGACCCAAGGTCATTTGGGGCAGCTTTAAAGGGAACAACACTAGGTA
ATTTATGGAAGTATCGAATTGGTGATTACCGCATCATTGCAGATATTGAAGATAATGTGATGCGGATTTTGGTTGTCCGA
ATTGGTAATAGAAGAGAAATTTATAAAAAAGCCGTCAGGCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT178276 WP_001307405.1 NZ_CP063459:c1655521-1655186 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT178276 NZ_CP083901:c19622-19398 [Zymomonas mobilis]
ATGTTAGCGATCAGACTACCAGAAGAAATAGAAGACCGTTTAAGTGCATTAGCCAATGCAACAGGTAGAACTAAGACTTT
CTATGCCAGAGAAGCCATACTTCATCATTTGGAAGAGCTTGAGGATATTTATCTAGCAGAAGCGCGCGCAGTTAAAATCC
GTTCCGGCCAGACTAAGACTGTCCCATTAGAAAATATTATGGCCGAATATGGCTTGGAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References