Detailed information of TA system TA178266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4574840..4575494
• Replicon: chromosome
• Accession: NZ_CP063455
• Organism: Pseudomonas protegens strain PC-578039

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IP586_RS20700
• Protein ID: WP_253085158.1
• Coordinates: 4574840..4575190 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IP586_RS20705
• Protein ID: WP_253085202.1
• Coordinates: 4575180..4575494 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP586_RS20690	4571599..4573131	+	1533	WP_011062195.1	NADH-quinone oxidoreductase subunit M	-
IP586_RS20695	4573139..4574602	+	1464	WP_015636299.1	NADH-quinone oxidoreductase subunit NuoN	-
IP586_RS20700	4574840..4575190	+	351	WP_253085158.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IP586_RS20705	4575180..4575494	+	315	WP_253085202.1	transcriptional regulator	Antitoxin
IP586_RS20710	4575563..4576945	-	1383	WP_102881792.1	cysteine--tRNA ligase	-
IP586_RS20715	4576964..4578664	-	1701	WP_102881793.1	glutamine--tRNA ligase/YqeY domain fusion protein	-
IP586_RS20720	4578935..4579438	+	504	WP_016965727.1	peptidylprolyl isomerase	-
IP586_RS20725	4579435..4580187	+	753	WP_170003879.1	UDP-2,3-diacylglucosamine diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-100)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13989.09 Da
• Isoelectric Point: 8.9833

>T178266 WP_253085158.1 NZ_CP063455:4574840-4575190 [Pseudomonas protegens]
MNALFIELPAFARYRKDFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFVDERRNKGRRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQHRQQLKQLLEREIEARRHDQT

Nucleotide

• Length: 351 bp

>T178266 NZ_CP083888:c4442499-4442113 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11967.79 Da
• Isoelectric Point: 10.4439

>AT178266 WP_253085202.1 NZ_CP063455:4575180-4575494 [Pseudomonas protegens]
IKRDIFSELVEGIDALTQERQGKITLRSHKVKLDKLPPITATEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATPN
AQATTLMRLVERYPDTVERLASLA

Nucleotide

• Length: 315 bp

>AT178266 NZ_CP083888:c4443038-4442529 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA