178139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5602804..5603399 Replicon chromosome
Accession NZ_CP063395
Organism Pseudomonas aeruginosa strain ST167_d57blood

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag IPV39_RS26000 Protein ID WP_003113526.1
Coordinates 5603121..5603399 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IPV39_RS25995 Protein ID WP_003113527.1
Coordinates 5602804..5603109 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV39_RS25970 (IPV39_25975) 5597962..5598297 + 336 WP_034035738.1 hypothetical protein -
IPV39_RS25975 (IPV39_25980) 5598307..5598696 + 390 WP_096219661.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
IPV39_RS25980 (IPV39_25985) 5598689..5599513 + 825 WP_096219662.1 HNH endonuclease -
IPV39_RS25985 (IPV39_25990) 5599889..5601649 - 1761 WP_132764182.1 HEPN domain-containing protein -
IPV39_RS25990 (IPV39_25995) 5602054..5602467 - 414 WP_049876905.1 hypothetical protein -
IPV39_RS25995 (IPV39_26000) 5602804..5603109 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
IPV39_RS26000 (IPV39_26005) 5603121..5603399 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IPV39_RS26005 5603452..5603580 - 129 Protein_5148 integrase -
IPV39_RS26010 (IPV39_26010) 5603728..5605956 + 2229 WP_023086667.1 TonB-dependent receptor -
IPV39_RS26015 (IPV39_26015) 5606026..5606673 - 648 WP_003095021.1 carbonate dehydratase -
IPV39_RS26020 (IPV39_26020) 5606735..5607973 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T178139 WP_003113526.1 NZ_CP063395:c5603399-5603121 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T178139 NZ_CP083867:147819-147968 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT178139 WP_003113527.1 NZ_CP063395:c5603109-5602804 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT178139 NZ_CP083867:c147775-147714 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References