178097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5617385..5617980 Replicon chromosome
Accession NZ_CP063388
Organism Pseudomonas aeruginosa strain ST1076_d100blood1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag IPV46_RS26250 Protein ID WP_003113526.1
Coordinates 5617702..5617980 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag IPV46_RS26245 Protein ID WP_003111575.1
Coordinates 5617385..5617690 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV46_RS26220 (IPV46_26215) 5612397..5612669 - 273 WP_003115921.1 hypothetical protein -
IPV46_RS26225 (IPV46_26220) 5613444..5615330 + 1887 WP_071550095.1 ATP-binding protein -
IPV46_RS26230 5615509..5615781 + 273 WP_071550096.1 DNA-binding protein -
IPV46_RS26235 (IPV46_26225) 5615837..5616169 + 333 WP_024947075.1 hypothetical protein -
IPV46_RS26240 (IPV46_26230) 5616429..5617043 + 615 WP_123794473.1 hypothetical protein -
IPV46_RS26245 (IPV46_26235) 5617385..5617690 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
IPV46_RS26250 (IPV46_26240) 5617702..5617980 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IPV46_RS26255 5618033..5618161 - 129 Protein_5198 integrase -
IPV46_RS26260 (IPV46_26245) 5618309..5620537 + 2229 WP_031686603.1 TonB-dependent receptor -
IPV46_RS26265 (IPV46_26250) 5620608..5621255 - 648 WP_003095021.1 carbonate dehydratase -
IPV46_RS26270 (IPV46_26255) 5621317..5622555 - 1239 WP_031686604.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T178097 WP_003113526.1 NZ_CP063388:c5617980-5617702 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T178097 NZ_CP083849:4131907-4132317 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT178097 WP_003111575.1 NZ_CP063388:c5617690-5617385 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT178097 NZ_CP083849:4131660-4131926 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References