178085

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5609595..5610190 Replicon chromosome
Accession NZ_CP063386
Organism Pseudomonas aeruginosa strain ST1076_d118limb1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag IPV48_RS26230 Protein ID WP_003113526.1
Coordinates 5609912..5610190 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag IPV48_RS26225 Protein ID WP_003111575.1
Coordinates 5609595..5609900 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV48_RS26200 (IPV48_26190) 5604607..5604879 - 273 WP_003115921.1 hypothetical protein -
IPV48_RS26205 (IPV48_26195) 5605654..5607540 + 1887 WP_071550095.1 ATP-binding protein -
IPV48_RS26210 5607719..5607991 + 273 WP_071550096.1 DNA-binding protein -
IPV48_RS26215 (IPV48_26200) 5608047..5608379 + 333 WP_024947075.1 hypothetical protein -
IPV48_RS26220 (IPV48_26205) 5608639..5609253 + 615 WP_123794473.1 hypothetical protein -
IPV48_RS26225 (IPV48_26210) 5609595..5609900 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
IPV48_RS26230 (IPV48_26215) 5609912..5610190 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IPV48_RS26235 5610243..5610371 - 129 Protein_5192 integrase -
IPV48_RS26240 (IPV48_26220) 5610519..5612747 + 2229 WP_031686603.1 TonB-dependent receptor -
IPV48_RS26245 (IPV48_26225) 5612818..5613465 - 648 WP_003095021.1 carbonate dehydratase -
IPV48_RS26250 (IPV48_26230) 5613527..5614765 - 1239 WP_031686604.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T178085 WP_003113526.1 NZ_CP063386:c5610190-5609912 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T178085 NZ_CP083842:c2917840-2917487 [Enterobacter asburiae]
GTGTCGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTTACTTCGCTTGACGATACCGAACGCGCCAGCGTACTTGC
AGCCCTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCCGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT178085 WP_003111575.1 NZ_CP063386:c5609900-5609595 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT178085 NZ_CP083842:c2917482-2917180 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCCCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTCGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References