Detailed information of TA system TA178073

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4637765..4638267
• Replicon: chromosome
• Accession: NZ_CP063380
• Organism: Pectobacterium versatile strain ECC15

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IMY97_RS21050
• Protein ID: WP_107332237.1
• Coordinates: 4638013..4638267 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7W2E625
• Locus tag: IMY97_RS21045
• Protein ID: WP_039324900.1
• Coordinates: 4637765..4638016 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMY97_RS21030 (IMY97_21200)	4634168..4635127	+	960	WP_039470517.1	ABC transporter permease	-
IMY97_RS21035 (IMY97_21205)	4635120..4635986	+	867	WP_103942043.1	ABC transporter permease	-
IMY97_RS21040 (IMY97_21210)	4635983..4637689	+	1707	WP_188246974.1	ABC transporter ATP-binding protein	-
IMY97_RS21045 (IMY97_21215)	4637765..4638016	+	252	WP_039324900.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
IMY97_RS21050 (IMY97_21220)	4638013..4638267	+	255	WP_107332237.1	Txe/YoeB family addiction module toxin	Toxin
IMY97_RS21055 (IMY97_21225)	4638309..4639163	-	855	WP_040031929.1	helix-turn-helix domain-containing protein	-
IMY97_RS21060 (IMY97_21230)	4639188..4640027	-	840	WP_039534818.1	HTH-type transcriptional activator RhaS	-
IMY97_RS21065 (IMY97_21235)	4640364..4641854	+	1491	WP_180744550.1	rhamnulokinase	-
IMY97_RS21070 (IMY97_21240)	4641851..4643113	+	1263	WP_180744549.1	L-rhamnose isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10171.76 Da
• Isoelectric Point: 8.8560

>T178073 WP_107332237.1 NZ_CP063380:4638013-4638267 [Pectobacterium versatile]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITGDAMMIAAC
RYHY

Nucleotide

• Length: 255 bp

>T178073 NZ_CP083834:3698549-3698872 [Enterobacter asburiae]
ATGCACATTGCATCCGTACCGGCCACGGTGCCGGTTTCGTCGCGCCTGTCGCCAGTACAAGTGTGGCAGCAACTGTTAGC
GTATCTGCTGGAACACCATTACGGCTTGGCACTTAACGACACGCCATTCCACGACGACGCGACCATTCAGGAACATATCG
AGGCGGGGATAACTCTAGCCGATGCGGTGAATTTTCTGGTCGAAAAGTACGAACTGGTTCGTATCGATCGGAAGGGATTT
TCATGGCAAGAACAGACCCCCTTTATTACCGCAATGGATATTCTGCGTGCCAAAAAGAGCATTGGGCTGTTGCCCAGATC
TTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9367.64 Da
• Isoelectric Point: 4.6119

>AT178073 WP_039324900.1 NZ_CP063380:4637765-4638016 [Pectobacterium versatile]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Nucleotide

• Length: 252 bp

>AT178073 NZ_CP083834:3698194-3698517 [Enterobacter asburiae]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGTGGTACGTTTAACGAGGAGGAGGCACTGCGTCTGGATCAGGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCCGATACTCTCGGCTCTCACGGCTATGTTTACATCGTTATTTATTCTCAGGCATCTGCAACCAG
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A7W2E625