Detailed information of TA system TA178054

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 62685..62949
• Replicon: plasmid p108.7k
• Accession: NZ_CP063371
• Organism: Escherichia coli strain 1409

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Y6M3
• Locus tag: FOI11_RS24205
• Protein ID: WP_001331364.1
• Coordinates: 62797..62949 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	62685..62742 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOI11_RS24190	58872..59942	-	1071	WP_000151583.1	IncI1-type conjugal transfer protein TrbB	-
FOI11_RS24195	59961..61169	-	1209	WP_000121274.1	IncI1-type conjugal transfer protein TrbA	-
-	62685..62742	-	58	NuclAT_0	-	Antitoxin
-	62685..62742	-	58	NuclAT_0	-	Antitoxin
-	62685..62742	-	58	NuclAT_0	-	Antitoxin
-	62685..62742	-	58	NuclAT_0	-	Antitoxin
FOI11_RS24205	62797..62949	+	153	WP_001331364.1	Hok/Gef family protein	Toxin
FOI11_RS24210	63572..63868	+	297	WP_001275298.1	hypothetical protein	-
FOI11_RS24215	63933..64109	-	177	WP_001054904.1	hypothetical protein	-
FOI11_RS24220	64501..64710	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
FOI11_RS24225	64782..65444	-	663	WP_000653334.1	plasmid IncI1-type surface exclusion protein ExcA	-
FOI11_RS24230	65509..67671	-	2163	WP_000698351.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	tet(A) / sul1 / qacE / aac(3)-VIa / ant(3'')-Ia / dfrA1	-	1..108699	108699

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5775.13 Da
• Isoelectric Point: 8.7948

>T178054 WP_001331364.1 NZ_CP063371:62797-62949 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T178054 NZ_CP083830:c1110755-1110489 [Enterobacter asburiae]
ATGGTGTGGCAGCAGTTGTTAACGTATCTGCTGGAGCACCACTACGGCCTCACACTCAACGACACACCATTTCATGACGA
CACGGCCATTGAGGAGCATATCGATGCGGGGATAACGCTTGCCGATGCTGTTAATTTCCTGGTCGAAAAGTACGAACTGG
CTCGTATCGACCGCAAGGGATTTACATGGCGAGAGCAACCCCCCTTCATTACTGCAACGGATATTCTGCGTGCCAAAAAG
AACATCGGGCTGTTGCCCAGATCTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT178054 NZ_CP063371:c62742-62685 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A5W9M382

Antitoxin