Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4317657..4318350 Replicon chromosome
Accession NZ_CP063369
Organism Escherichia coli strain 1409

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FOI11_RS20640 Protein ID WP_000415584.1
Coordinates 4317657..4317953 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FOI11_RS20645 Protein ID WP_000650107.1
Coordinates 4317955..4318350 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOI11_RS20605 4312743..4313057 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
FOI11_RS20610 4313088..4313669 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FOI11_RS20615 4313988..4314322 + 335 Protein_4021 DUF2645 family protein -
FOI11_RS20620 4314368..4315717 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FOI11_RS20625 4315714..4316373 - 660 WP_032176610.1 two-component system response regulator QseB -
FOI11_RS20630 4316525..4316917 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FOI11_RS20635 4316970..4317452 + 483 WP_000183505.1 transcriptional regulator -
FOI11_RS20640 4317657..4317953 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FOI11_RS20645 4317955..4318350 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FOI11_RS20650 4318483..4320090 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FOI11_RS20655 4320228..4322486 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178043 WP_000415584.1 NZ_CP063369:4317657-4317953 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178043 NZ_CP083821:3286189-3286515 [Enterobacter cloacae subsp. cloacae]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCAGCGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGGC
GCGTTTGCTGGAACAGCACTACGGTCTGACAATAAACGACACCCCATTCAGCGATGAAGTTGTTATACAGCAACATATCG
ATGCCGGTATCACCCTGTCAGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTCCGTATCGACAGGAAGGGATTT
CGCTGGCAGGAACAATCCCCTTACCTTCGGGCTGTCGATATTCTGAGGGCAAGACAGGCAATAGGTCTTTTACGAGGATC
TCATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178043 WP_000650107.1 NZ_CP063369:4317955-4318350 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178043 NZ_CP083821:3285851-3286168 [Enterobacter cloacae subsp. cloacae]
ATGACCCACATCATCTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTACAGGAGGGCAACCGGCT
GCACTACCTGGCTGACCGGGCCAGCATCACCGGTATGTTCAGTGACGCCGAATGCCGGAAGCTGGATGACACATTCCCAC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCAACATGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGTGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References