Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4209733..4210532 Replicon chromosome
Accession NZ_CP063369
Organism Escherichia coli strain 1409

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag FOI11_RS20115 Protein ID WP_000347273.1
Coordinates 4209733..4210197 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag FOI11_RS20120 Protein ID WP_001307405.1
Coordinates 4210197..4210532 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOI11_RS20085 4204734..4205168 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
FOI11_RS20090 4205186..4206064 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
FOI11_RS20095 4206054..4206833 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
FOI11_RS20100 4206844..4207317 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
FOI11_RS20105 4207340..4208620 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
FOI11_RS20110 4208869..4209678 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FOI11_RS20115 4209733..4210197 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FOI11_RS20120 4210197..4210532 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FOI11_RS20125 4210681..4212252 - 1572 WP_001273753.1 galactarate dehydratase -
FOI11_RS20130 4212627..4213961 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
FOI11_RS20135 4213977..4214747 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T178041 WP_000347273.1 NZ_CP063369:c4210197-4209733 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T178041 NZ_CP083821:c2770121-2770018 [Enterobacter cloacae subsp. cloacae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT178041 WP_001307405.1 NZ_CP063369:c4210532-4210197 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT178041 NZ_CP083821:2770005-2770156 [Enterobacter cloacae subsp. cloacae]
CTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References