Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3396252..3396822 Replicon chromosome
Accession NZ_CP063361
Organism Massilia violaceinigra strain sipir

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag INH39_RS15640 Protein ID WP_167081787.1
Coordinates 3396544..3396822 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag INH39_RS15635 Protein ID WP_167081789.1
Coordinates 3396252..3396527 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INH39_RS15610 (INH39_15530) 3391584..3392147 - 564 WP_167081799.1 aminodeoxychorismate/anthranilate synthase component II -
INH39_RS15615 (INH39_15535) 3392149..3393645 - 1497 WP_167081797.1 anthranilate synthase component I -
INH39_RS15620 (INH39_15540) 3393839..3394552 - 714 WP_243493966.1 phosphoglycolate phosphatase -
INH39_RS15625 (INH39_15545) 3394722..3395594 + 873 WP_243493967.1 carboxypeptidase-like regulatory domain-containing protein -
INH39_RS15630 (INH39_15550) 3395632..3395970 + 339 WP_243493968.1 hypothetical protein -
INH39_RS15635 (INH39_15555) 3396252..3396527 - 276 WP_167081789.1 HigA family addiction module antitoxin Antitoxin
INH39_RS15640 (INH39_15560) 3396544..3396822 - 279 WP_167081787.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INH39_RS15645 (INH39_15565) 3397224..3397904 - 681 WP_243493969.1 hypothetical protein -
INH39_RS15650 (INH39_15570) 3397926..3398846 - 921 WP_243493970.1 hypothetical protein -
INH39_RS15655 (INH39_15575) 3398857..3399528 - 672 WP_166878176.1 ribulose-phosphate 3-epimerase -
INH39_RS15660 (INH39_15580) 3399709..3400083 + 375 WP_167081781.1 Co2+/Mg2+ efflux protein ApaG -
INH39_RS15665 (INH39_15585) 3400097..3400264 - 168 WP_243494354.1 hypothetical protein -
INH39_RS15670 (INH39_15590) 3400393..3401169 + 777 WP_243493971.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10436.88 Da        Isoelectric Point: 9.7794

>T178012 WP_167081787.1 NZ_CP063361:c3396822-3396544 [Massilia violaceinigra]
MIKTFRHKGLQRFFETGSKAGIQAAHAARLRLQLGALDQATRPEDLSAPSWDLHPLKGNLHGHWAITVNGNWRMIFAFDG
PDAILVDYRDYH

Download         Length: 279 bp

>T178012 NZ_CP083809:c4082828-4082535 [Pantoea agglomerans]
ATGCCACAAGTAATTGTTACCCAACGCGCCGCTAGCGGGCTGGCGCGTTGCCGTGAGTTTTTAATGAATAAGAATCCACT
TGCGGCGCTTAAAGCAGGTCAGGTGCTTGAAAAGCAGTTTGAACAACTGGAAAAAAACCCAGAAATCGGCCGACCTTTTG
TCGAAGCACCTCAACTACGAGAGCTCCTGATTGGCTTCGGCGATTCAGGCTATGTCGCGCTATACCGTTATGAACAGCAT
GAAGATCGTATCTATATTTTAGCCTTCCGCCATCAGAAAGAAGCTGGCTACTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9878.36 Da        Isoelectric Point: 9.9770

>AT178012 WP_167081789.1 NZ_CP063361:c3396527-3396252 [Massilia violaceinigra]
MTRMHNPPHPGEVLREYLGGMTVTEAAGRLGVSRVTLQRVVSGAAGVSPDMAYRLGTAFGTSPEFWAGMQLQYDLYQAGK
IKRPGIERITA

Download         Length: 276 bp

>AT178012 NZ_CP083809:c4083097-4082816 [Pantoea agglomerans]
ATGCCAACCACCAGCACCACACTGAAGATTGACAGCCTTCTTAAAGAGCGCGTGAAAAAACTGGCGGATTCTCGGGACCG
CAGCCCGCACTACCTCATGGTCACCGCTATTGCTCAGTACATCGAGCGAGAAGAGGCGCGTGAAAGCTTTAAGCAAGAGG
CCCTGGATTCATGGCGTGAATATCAGGAAACGGGCCTGCATCTCACCGGTGAAGAAGTGAAAAGCTGGTTACGCAACTGG
GGGACGGAGGCGGAAACGGATATTCCTGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References