Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4588094..4588754 Replicon chromosome
Accession NZ_CP063354
Organism Serratia marcescens strain SCQ1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CA266_RS21820 Protein ID WP_049298854.1
Coordinates 4588401..4588754 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag CA266_RS21815 Protein ID WP_016927038.1
Coordinates 4588094..4588396 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA266_RS21795 4583710..4584624 - 915 WP_016927041.1 branched-chain amino acid ABC transporter permease -
CA266_RS21800 4584748..4585866 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
CA266_RS21810 4586471..4587679 - 1209 WP_079449935.1 aldose 1-epimerase family protein -
CA266_RS21815 4588094..4588396 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
CA266_RS21820 4588401..4588754 - 354 WP_049298854.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA266_RS21825 4589193..4590488 + 1296 WP_028127724.1 MFS transporter -
CA266_RS21830 4590516..4591322 + 807 WP_151254638.1 substrate-binding domain-containing protein -
CA266_RS21835 4591297..4592196 - 900 WP_164053047.1 LysR family transcriptional regulator -
CA266_RS21840 4592301..4592666 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13486.38 Da        Isoelectric Point: 9.4805

>T178007 WP_049298854.1 NZ_CP063354:c4588754-4588401 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQRRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T178007 NZ_CP083809:1495141-1495494 [Pantoea agglomerans]
GTGTGGGCTATAAAAACCACGGTCAGATTCGATCGCTGGTTTACACAGCTGTGCGATAGCGACCGGGCCAGCGTACTGGC
TGCGATGATCGCCCTTCAGGAGAGAGGGCCGGGGTTGCCCAGACCCTATGCTGATACGCTTAAAGGTTCGCGCTACATCA
ATATGAAAGAGTTGCGCATTCAGTGTCGAGGTCATCCCATTCGGGCATTTTTTGCCTTTGACCCCGACCGTACGGGAGTT
TTGCTTTGTGCCGGTCACAAAGCTGGCAATGAAAAACGATTTTACGCTGAAATGATCCCAGCAGCCGACCGGGAGTTTAC
CGGGTGGCTTAAGGGGTTAAGAGAAAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT178007 WP_016927038.1 NZ_CP063354:c4588396-4588094 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT178007 NZ_CP083809:1495499-1495801 [Pantoea agglomerans]
ATGGGCAGAACGCTTGAACAGCTTATTGCAGATGAAAAACCCGAGGTGGCTGCTGAAGCAGAGCGCTCGGCCGCTGAGAT
TCTGCTGAATATTCATCTGGCTGAACTGCGCGAAAAGGTGCAGAAAACCCAGGTTGAGATGGCGCAGACGCTGGGCATCA
GGCAGCCCACCGTGGCAGGCATGGAAAAACCGGGACGCGATCTGCGCCTCTCTACGCTGAAGCGCTATGTGGAGGCGGCA
GGCGGCAAACTGCATCTCGATATTGAGCTGCCGGATGGCACGCACTATGGGTTTCAGGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References