Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 723415..724043 Replicon chromosome
Accession NZ_CP063354
Organism Serratia marcescens strain SCQ1

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag CA266_RS03370 Protein ID WP_016930174.1
Coordinates 723415..723705 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CA266_RS03375 Protein ID WP_016930175.1
Coordinates 723720..724043 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA266_RS03360 719829..721850 + 2022 WP_193843100.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
CA266_RS03365 722045..723184 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
CA266_RS03370 723415..723705 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA266_RS03375 723720..724043 + 324 WP_016930175.1 HigA family addiction module antidote protein Antitoxin
CA266_RS03380 724036..724548 + 513 WP_016930176.1 M48 family metallopeptidase -
CA266_RS03385 724599..725579 + 981 WP_025304343.1 Gfo/Idh/MocA family oxidoreductase -
CA266_RS03390 725581..726312 + 732 WP_016930178.1 glutamine amidotransferase -
CA266_RS03395 726568..727533 + 966 WP_028127587.1 TerC family protein -
CA266_RS03400 727796..729031 + 1236 WP_049299890.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T177994 WP_016930174.1 NZ_CP063354:723415-723705 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T177994 NZ_CP083804:3281018-3281275 [Xanthomonas translucens pv. pistacia]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAAACCGACAAGAAGATGCTCAAGCGCGT
CAACGATCTGATCAAAGCCATTCAACGCGATCCCTTCCAAGGCGTCGGCAAGCCAGAACCGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACATCGCATCGTGTACAAGGTCGAGGCGGGCGTCCTGCTGATCGCGCAGGTG
CGGTATCACTACGCGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT177994 WP_016930175.1 NZ_CP063354:723720-724043 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT177994 NZ_CP083804:3280770-3281021 [Xanthomonas translucens pv. pistacia]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGCGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAAGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References