Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3725120..3725661 Replicon chromosome
Accession NZ_CP063341
Organism Escherichia coli strain BS90R-A

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag IN877_RS17930 Protein ID WP_000615976.1
Coordinates 3725383..3725661 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag IN877_RS17925 Protein ID WP_000729704.1
Coordinates 3725120..3725380 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IN877_RS17900 3720156..3721295 + 1140 WP_097447642.1 flagellar type III secretion system protein FlhB -
IN877_RS17905 3721279..3723372 + 2094 WP_001583165.1 flagellar biosynthesis protein FlhA -
IN877_RS17910 3723477..3723755 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
IN877_RS17915 3723748..3724104 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
IN877_RS17920 3724161..3724934 - 774 WP_000543899.1 C40 family peptidase -
IN877_RS17925 3725120..3725380 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IN877_RS17930 3725383..3725661 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IN877_RS17935 3725817..3726557 + 741 WP_001225679.1 murein L,D-transpeptidase -
IN877_RS17940 3726528..3727295 - 768 WP_000333380.1 class II glutamine amidotransferase -
IN877_RS17945 3727501..3728079 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T177953 WP_000615976.1 NZ_CP063341:3725383-3725661 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T177953 NZ_CP083784:1829477-1829579 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT177953 WP_000729704.1 NZ_CP063341:3725120-3725380 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT177953 NZ_CP083784:c1829586-1829441 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References