Detailed information of TA system TA177896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1278747..1279249
• Replicon: chromosome
• Accession: NZ_CP063314
• Organism: Proteus vulgaris strain LC-693

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IM703_RS05845
• Protein ID: WP_196554397.1
• Coordinates: 1278747..1279001 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IM703_RS05850
• Protein ID: WP_072068851.1
• Coordinates: 1278998..1279249 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM703_RS05820	1274081..1274578	-	498	WP_072068857.1	Der GTPase-activating protein YihI	-
IM703_RS05825	1274767..1276239	+	1473	WP_196554398.1	glycosyltransferase family 39 protein	-
IM703_RS05830	1276242..1276790	+	549	WP_072068855.1	GNAT family N-acetyltransferase	-
IM703_RS05835	1276840..1277151	-	312	WP_072068854.1	monooxygenase	-
IM703_RS05840	1277231..1278589	-	1359	WP_197269775.1	NCS2 family permease	-
IM703_RS05845	1278747..1279001	-	255	WP_196554397.1	Txe/YoeB family addiction module toxin	Toxin
IM703_RS05850	1278998..1279249	-	252	WP_072068851.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
IM703_RS05855	1279375..1279779	+	405	WP_197269776.1	DUF1240 domain-containing protein	-
IM703_RS05860	1279782..1280186	+	405	WP_072068849.1	DUF1240 domain-containing protein	-
IM703_RS05865	1280437..1281183	-	747	WP_196554395.1	amino acid ABC transporter permease	-
IM703_RS05870	1281185..1281922	-	738	WP_115351110.1	amino acid ABC transporter permease	-
IM703_RS05875	1282030..1282869	-	840	WP_197269777.1	ABC transporter substrate-binding protein	-
IM703_RS05880	1283085..1283819	-	735	WP_072068845.1	phosphate signaling complex protein PhoU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10198.85 Da
• Isoelectric Point: 9.9411

>T177896 WP_196554397.1 NZ_CP063314:c1279001-1278747 [Proteus vulgaris]
MKLIFSEQSWSDYLYWQQMDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDPAIEIASC
RYHY

Nucleotide

• Length: 255 bp

>T177896 NZ_CP083752:32364-32834 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.77 Da
• Isoelectric Point: 4.4354

>AT177896 WP_072068851.1 NZ_CP063314:c1279249-1278998 [Proteus vulgaris]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Nucleotide

• Length: 252 bp

>AT177896 NZ_CP083752:31924-32367 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA