Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 916111..916805 Replicon chromosome
Accession NZ_CP063303
Organism Yersinia pestis strain 14D

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag IM067_RS03795 Protein ID WP_002214787.1
Coordinates 916111..916407 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag IM067_RS03800 Protein ID WP_002209924.1
Coordinates 916407..916805 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM067_RS03765 (IM067_03770) 911233..912750 + 1518 WP_002209930.1 lysine--tRNA ligase -
IM067_RS03775 (IM067_03780) 913183..914397 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
IM067_RS03780 (IM067_03785) 914479..914664 - 186 WP_002209928.1 hypothetical protein -
IM067_RS20990 914765..914890 - 126 WP_002214784.1 hypothetical protein -
IM067_RS03785 (IM067_03790) 915262..915522 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
IM067_RS03790 (IM067_03795) 915585..915947 + 363 WP_002209925.1 helix-turn-helix transcriptional regulator -
IM067_RS03795 (IM067_03800) 916111..916407 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
IM067_RS03800 (IM067_03805) 916407..916805 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
IM067_RS03805 (IM067_03810) 917205..919496 - 2292 WP_002209923.1 primase-like DNA-binding domain-containing protein -
IM067_RS03810 (IM067_03815) 919796..920122 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
IM067_RS03815 (IM067_03820) 920115..920267 + 153 WP_002209921.1 hypothetical protein -
IM067_RS03820 (IM067_03825) 920281..920481 - 201 WP_002209920.1 AlpA family transcriptional regulator -
IM067_RS03825 (IM067_03830) 920663..920995 - 333 WP_002214791.1 hypothetical protein -
IM067_RS03830 (IM067_03835) 921001..921237 - 237 WP_002214792.1 hypothetical protein -
IM067_RS03835 (IM067_03840) 921250..921615 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T177881 WP_002214787.1 NZ_CP063303:916111-916407 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T177881 NZ_CP083746:c4398208-4398026 [Pseudomonas sp. p1(2021b)]
ATGCGCAGTAGGGACGTGATCCAACTCATCGAAGCGGATGGGTGGTATGAGGTGGAGGTGAAAGGAAGCCATCATCAGTT
CAGGCATCCCATAAAGCGAGGAAGGGTTACGGTTCCCCATCCTAAAAGTGATTTGCCAAAGGGCACTGTGCACAACATCT
TGAAACAAGCTGGCCTGAAGTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT177881 WP_002209924.1 NZ_CP063303:916407-916805 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT177881 NZ_CP083746:c4397969-4397562 [Pseudomonas sp. p1(2021b)]
ATGAAGTTCCCAGTCGTATTGCACAAAGACGTTGACTCGGACTACGGCGTCATCGTGCCTGATGTACCTGGCTGTTTCTC
CGCCGGTGCTAGCGTCGCTCAAGCGCTGGAGAATGTTCAGGAGGCTCTGACGTTGCATTTCGAAGGGCTGATGGCGGATG
GAGAGACGCTGCCACAAGCGCAAGAAGTTGATGTTCATGTCGCGAATCCCGATTACGCCGGAGGAATATGGGCGGTCGTG
GATTTTGATGTGACGCCCTATCTGGGCAAGGCGGTGCGTTTCAACGCCACGCTGCCAGAGAACCTGTTGCAACGCATCGA
TGAGAAAGTGAAACGTGATCATCGATATGCTTCTCGCTCCGGCTTCTTGGCCTCGGCCGCTTTGCGTGAGTTGGCTGCGG
CGCATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References