Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4697759..4698489 Replicon chromosome
Accession NZ_CP063238
Organism Serratia marcescens strain SCH909

Toxin (Protein)


Gene name higB Uniprot ID A0A2S4X738
Locus tag SCH909_RS22425 Protein ID WP_033636137.1
Coordinates 4697759..4698070 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GBG9
Locus tag SCH909_RS22430 Protein ID WP_033636138.1
Coordinates 4698067..4698489 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCH909_RS22395 4693070..4693795 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
SCH909_RS22400 4693848..4695281 + 1434 WP_033648997.1 RNA polymerase factor sigma-54 -
SCH909_RS22405 4695305..4695592 + 288 WP_004937038.1 ribosome hibernation promoting factor -
SCH909_RS22410 4695748..4696209 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
SCH909_RS22415 4696339..4697193 + 855 WP_015379177.1 RNase adapter RapZ -
SCH909_RS22420 4697190..4697462 + 273 WP_033648996.1 PTS phosphocarrier protein NPr -
SCH909_RS22425 4697759..4698070 + 312 WP_033636137.1 type II toxin-antitoxin system HigB family toxin Toxin
SCH909_RS22430 4698067..4698489 + 423 WP_033636138.1 helix-turn-helix domain-containing protein Antitoxin
SCH909_RS22435 4698494..4700410 - 1917 WP_033648995.1 BglG family transcription antiterminator -
SCH909_RS22440 4700462..4701676 - 1215 WP_060422826.1 lactonase family protein -
SCH909_RS22445 4701771..4702511 - 741 WP_033648993.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12259.11 Da        Isoelectric Point: 10.0957

>T177813 WP_033636137.1 NZ_CP063238:4697759-4698070 [Serratia marcescens]
MHIISREPFNNATKQYPNEAAALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T177813 NZ_CP083701:c3086368-3086018 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15676.97 Da        Isoelectric Point: 4.9590

>AT177813 WP_033636138.1 NZ_CP063238:4698067-4698489 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSSSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVSQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT177813 NZ_CP083701:c3086613-3086362 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4X738

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GBG9

References