Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4281048..4281700 Replicon chromosome
Accession NZ_CP063238
Organism Serratia marcescens strain SCH909

Toxin (Protein)


Gene name higB Uniprot ID A0A2V4FMR7
Locus tag SCH909_RS20475 Protein ID WP_060422174.1
Coordinates 4281048..4281392 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag SCH909_RS20480 Protein ID WP_004931828.1
Coordinates 4281398..4281700 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCH909_RS20465 4277390..4279648 - 2259 WP_060422177.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
SCH909_RS20470 4279869..4280888 + 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
SCH909_RS20475 4281048..4281392 + 345 WP_060422174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SCH909_RS20480 4281398..4281700 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
SCH909_RS20485 4281728..4282990 - 1263 WP_049212615.1 diaminopimelate decarboxylase -
SCH909_RS20490 4283124..4284047 + 924 WP_060422171.1 LysR family transcriptional regulator -
SCH909_RS20495 4284075..4284983 - 909 WP_015378928.1 LysR family transcriptional regulator -
SCH909_RS20500 4285092..4285976 + 885 WP_060422168.1 MBL fold metallo-hydrolase -
SCH909_RS20505 4286045..4286692 + 648 WP_033649493.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13425.52 Da        Isoelectric Point: 10.6087

>T177811 WP_060422174.1 NZ_CP063238:4281048-4281392 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDLQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T177811 NZ_CP083701:c2639935-2639537 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT177811 WP_004931828.1 NZ_CP063238:4281398-4281700 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT177811 NZ_CP083701:c2640231-2639938 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FMR7

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References