Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3356698..3357300 Replicon chromosome
Accession NZ_CP063214
Organism Escherichia coli strain ERP001

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IL987_RS16280 Protein ID WP_193579169.1
Coordinates 3356698..3356970 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IL987_RS16285 Protein ID WP_000356397.1
Coordinates 3357010..3357300 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL987_RS16255 3352612..3353211 + 600 WP_001298594.1 glucose-1-phosphatase -
IL987_RS16260 3353205..3354077 + 873 WP_000920762.1 virulence factor BrkB family protein -
IL987_RS16265 3354074..3354511 + 438 WP_000560990.1 D-tyrosyl-tRNA(Tyr) deacylase -
IL987_RS16270 3354556..3355497 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
IL987_RS16275 3355561..3356469 - 909 WP_001331553.1 alpha/beta hydrolase -
IL987_RS16280 3356698..3356970 + 273 WP_193579169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IL987_RS16285 3357010..3357300 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
IL987_RS16290 3357659..3357937 + 279 WP_001296612.1 hypothetical protein -
IL987_RS16295 3358333..3358551 + 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
IL987_RS16300 3358767..3359696 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
IL987_RS16305 3359693..3360328 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
IL987_RS16310 3360325..3361227 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10543.18 Da        Isoelectric Point: 7.3158

>T177719 WP_193579169.1 NZ_CP063214:3356698-3356970 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
HKGIKDDLSP

Download         Length: 273 bp

>T177719 NZ_CP083638:3864463-3864570 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT177719 WP_000356397.1 NZ_CP063214:3357010-3357300 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT177719 NZ_CP083638:c3864414-3864351 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References