Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
| Location | 935163..935758 | Replicon | chromosome |
| Accession | NZ_CP063194 | ||
| Organism | Corynebacterium jeddahense strain DSM 45997 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | - |
| Locus tag | CJEDD_RS04640 | Protein ID | WP_074432522.1 |
| Coordinates | 935163..935444 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CJEDD_RS04645 | Protein ID | WP_042407232.1 |
| Coordinates | 935453..935758 (+) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CJEDD_RS04590 (CJEDD_04525) | 930659..931189 | - | 531 | WP_052333787.1 | IS3 family transposase | - |
| CJEDD_RS04595 (CJEDD_04530) | 931339..931497 | - | 159 | WP_074432524.1 | IS3 family transposase | - |
| CJEDD_RS04600 (CJEDD_04535) | 931647..932144 | - | 498 | WP_042407246.1 | DUF1707 domain-containing protein | - |
| CJEDD_RS04605 (CJEDD_04540) | 932193..932966 | + | 774 | WP_042407245.1 | MerR family transcriptional regulator | - |
| CJEDD_RS04610 (CJEDD_04545) | 933137..933580 | - | 444 | WP_042407240.1 | alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB | - |
| CJEDD_RS04615 (CJEDD_04550) | 933644..933862 | - | 219 | WP_042407237.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CJEDD_RS04620 (CJEDD_04555) | 933939..934154 | - | 216 | WP_042407235.1 | DUF6290 family protein | - |
| CJEDD_RS04625 (CJEDD_04560) | 934258..934392 | - | 135 | WP_269744998.1 | hypothetical protein | - |
| CJEDD_RS04630 (CJEDD_04565) | 934486..934836 | - | 351 | WP_042407272.1 | VOC family protein | - |
| CJEDD_RS04635 | 934893..935039 | - | 147 | WP_157034468.1 | toxin-antitoxin system antitoxin subunit | - |
| CJEDD_RS04640 (CJEDD_04570) | 935163..935444 | + | 282 | WP_074432522.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CJEDD_RS04645 (CJEDD_04575) | 935453..935758 | + | 306 | WP_042407232.1 | HigA family addiction module antitoxin | Antitoxin |
| CJEDD_RS04650 (CJEDD_04580) | 935806..936249 | - | 444 | WP_042407230.1 | alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB | - |
| CJEDD_RS04655 | 936298..936510 | - | 213 | WP_042407227.1 | DUF6290 family protein | - |
| CJEDD_RS04660 (CJEDD_04585) | 936513..937841 | - | 1329 | WP_042407223.1 | hypothetical protein | - |
| CJEDD_RS04665 (CJEDD_04590) | 937951..938370 | + | 420 | WP_042407220.1 | VOC family protein | - |
| CJEDD_RS04670 (CJEDD_04595) | 938413..938796 | - | 384 | WP_052333786.1 | FUSC family protein | - |
| CJEDD_RS04675 (CJEDD_04600) | 938769..939050 | - | 282 | WP_052333785.1 | hypothetical protein | - |
| CJEDD_RS04680 (CJEDD_04605) | 939140..939745 | - | 606 | WP_042407215.1 | DUF308 domain-containing protein | - |
| CJEDD_RS04685 (CJEDD_04610) | 939891..940247 | + | 357 | WP_052333784.1 | hypothetical protein | - |
| CJEDD_RS04690 (CJEDD_04615) | 940306..940695 | + | 390 | WP_232297711.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | erm(X) | - | 893247..970539 | 77292 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10749.26 Da Isoelectric Point: 10.1984
>T177685 WP_074432522.1 NZ_CP063194:935163-935444 [Corynebacterium jeddahense]
MIQSFGNRETELVFLREPVPKLDPRIHKSANKKLHQLDAAVSLDSLRVPPGNRLEALKGDRKGAFSIRVNDQWRITFRWK
DAGPEQVTIEDYH
MIQSFGNRETELVFLREPVPKLDPRIHKSANKKLHQLDAAVSLDSLRVPPGNRLEALKGDRKGAFSIRVNDQWRITFRWK
DAGPEQVTIEDYH
Download Length: 282 bp
>T177685 NZ_CP083630:1043189-1043476 [Leclercia adecarboxylata]
ATGGCGTATTTACTGGATTTTGACGAGCGCGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGCAGAAGTACTTGAGTCACCCCGAATTGAAGTGAATAAGCTTCGTGGTATGCCTGACTGTTACAAGATAA
AGCTCAAGTCTTCGGGATATCGCCTTGTATATCAGGTTATAGACGAGAAGGTTGTCGTCTTCGTGGTTTCTGTTGGGAAA
AGAGAACGCTCTAAAGTGTATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTACTGGATTTTGACGAGCGCGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGCAGAAGTACTTGAGTCACCCCGAATTGAAGTGAATAAGCTTCGTGGTATGCCTGACTGTTACAAGATAA
AGCTCAAGTCTTCGGGATATCGCCTTGTATATCAGGTTATAGACGAGAAGGTTGTCGTCTTCGTGGTTTCTGTTGGGAAA
AGAGAACGCTCTAAAGTGTATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11352.08 Da Isoelectric Point: 5.6174
>AT177685 WP_042407232.1 NZ_CP063194:935453-935758 [Corynebacterium jeddahense]
MSNKLYPPIHPGEILLEDFIEGFGITQHKLAVSIGVPPRRINEIVHGKRGITADTALRLGKYFGVEPIFWMNLQNQYEIE
LAEDRALAEIERIQPVQAASA
MSNKLYPPIHPGEILLEDFIEGFGITQHKLAVSIGVPPRRINEIVHGKRGITADTALRLGKYFGVEPIFWMNLQNQYEIE
LAEDRALAEIERIQPVQAASA
Download Length: 306 bp
>AT177685 NZ_CP083630:1042950-1043189 [Leclercia adecarboxylata]
ATGGGTAGCATAAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTTACTCC
CTCTGAAGCGCTTCGTCTCATGCTTGAATATATCGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGACGCTGAACTCGTGGAGATAGTGAAAGAGCGTCTTCGCAATCCTAAGCCAGTACGTGTGACACTGGATGAGCTCTGA
ATGGGTAGCATAAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTTACTCC
CTCTGAAGCGCTTCGTCTCATGCTTGAATATATCGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGACGCTGAACTCGTGGAGATAGTGAAAGAGCGTCTTCGCAATCCTAAGCCAGTACGTGTGACACTGGATGAGCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|