Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 818361..818953 Replicon chromosome
Accession NZ_CP063190
Organism Corynebacterium ihumii strain DSM 45751

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CIHUM_RS04140 Protein ID WP_074432060.1
Coordinates 818361..818639 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CIHUM_RS04145 Protein ID WP_034999634.1
Coordinates 818648..818953 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIHUM_RS04115 (CIHUM_04100) 813406..814092 - 687 WP_187370393.1 hypothetical protein -
CIHUM_RS04120 (CIHUM_04105) 814104..815150 - 1047 WP_034999630.1 DNA recombination protein RmuC -
CIHUM_RS04125 (CIHUM_04110) 815182..816564 - 1383 WP_243427163.1 AI-2E family transporter -
CIHUM_RS04130 (CIHUM_04115) 816659..817744 + 1086 WP_034999632.1 redox-regulated ATPase YchF -
CIHUM_RS04135 (CIHUM_04120) 817745..818095 - 351 WP_034999969.1 VOC family protein -
CIHUM_RS04140 818361..818639 + 279 WP_074432060.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIHUM_RS04145 (CIHUM_04125) 818648..818953 + 306 WP_034999634.1 HigA family addiction module antitoxin Antitoxin
CIHUM_RS04150 (CIHUM_04130) 819030..819473 - 444 WP_034999636.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
CIHUM_RS04155 (CIHUM_04135) 819559..820632 - 1074 WP_051106457.1 FUSC family protein -
CIHUM_RS04160 (CIHUM_04140) 820775..821614 + 840 WP_034999639.1 type II CAAX endopeptidase family protein -
CIHUM_RS04165 (CIHUM_04145) 821626..822783 + 1158 WP_034999641.1 chromate efflux transporter -
CIHUM_RS04170 (CIHUM_04150) 822844..823944 + 1101 Protein_807 Dyp-type peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10543.99 Da        Isoelectric Point: 10.2000

>T177684 WP_074432060.1 NZ_CP063190:818361-818639 [Corynebacterium ihumii]
IQSFGNRETELVFLREPVPKLDPRIHKSANKKLHQLDAAVSLDSLLVPPGNRLEALKGDRKGTFSTRVNDQWRITFRWKG
AGPEHVTIEDYH

Download         Length: 279 bp

>T177684 NZ_CP083630:993213-993315 [Leclercia adecarboxylata]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11296.01 Da        Isoelectric Point: 5.0995

>AT177684 WP_034999634.1 NZ_CP063190:818648-818953 [Corynebacterium ihumii]
MSNKLYPPIHPGEILLEDFIEGFGITQHKLAVSIGVPPRRINEIVHGKRGITADTALRLGKYFGVEPIFWMNLQNQYEIE
LAEDKALAEIEQIQPVQAASA

Download         Length: 306 bp

>AT177684 NZ_CP083630:c993317-993177 [Leclercia adecarboxylata]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCACTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References