Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 379063..379702 Replicon chromosome
Accession NZ_CP063127
Organism Haemophilus influenzae strain M1C112_1

Toxin (Protein)


Gene name higB Uniprot ID A0A1B8PGE6
Locus tag INP89_RS01795 Protein ID WP_012054677.1
Coordinates 379063..379368 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID H1LMA4
Locus tag INP89_RS01800 Protein ID WP_009499989.1
Coordinates 379379..379702 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP89_RS01775 374493..376532 - 2040 WP_074039806.1 excinuclease ABC subunit B -
INP89_RS01785 377147..378115 - 969 WP_074039804.1 zinc transporter permease subunit ZevB -
INP89_RS01790 378118..378738 - 621 WP_074039803.1 zinc transporter binding subunit ZevA -
INP89_RS01795 379063..379368 + 306 WP_012054677.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INP89_RS01800 379379..379702 + 324 WP_009499989.1 HigA family addiction module antidote protein Antitoxin
INP89_RS01805 379867..381537 + 1671 WP_012054676.1 energy-dependent translational throttle protein EttA -
INP89_RS01810 381599..381940 + 342 WP_005666735.1 SirB2 family protein -
INP89_RS01815 381945..383789 + 1845 WP_012054674.1 tRNA(Met) cytidine acetyltransferase TmcA -
INP89_RS01820 383786..383959 + 174 WP_012054673.1 DUF5363 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12180.80 Da        Isoelectric Point: 8.3426

>T177587 WP_012054677.1 NZ_CP063127:379063-379368 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDAHSKIPSNLSKVLARKLDMISAAEDINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T177587 NZ_CP083585:1995494-1995597 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12302.14 Da        Isoelectric Point: 7.4050

>AT177587 WP_009499989.1 NZ_CP063127:379379-379702 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKINDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKAFDTTPEFWLNLQTRIDLWEL
EHNKRFQQSLANVKPALHRHGTSTFAM

Download         Length: 324 bp

>AT177587 NZ_CP083585:c1995635-1995364 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8PGE6

Antitoxin

Source ID Structure
AlphaFold DB H1LMA4

References