Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2087072..2087741 Replicon chromosome
Accession NZ_CP063056
Organism Rodentibacter sp. DSM 111151

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IHV77_RS10015 Protein ID WP_194811814.1
Coordinates 2087382..2087741 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHV77_RS10010 Protein ID WP_194811813.1
Coordinates 2087072..2087380 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHV77_RS09990 2082161..2082565 + 405 WP_194811809.1 hypothetical protein -
IHV77_RS09995 2082574..2082903 + 330 WP_194811810.1 hypothetical protein -
IHV77_RS10000 2083008..2083337 + 330 WP_194811811.1 phage tail protein -
IHV77_RS10005 2083388..2086729 + 3342 WP_194811812.1 phage tail tape measure protein -
IHV77_RS10010 2087072..2087380 - 309 WP_194811813.1 helix-turn-helix transcriptional regulator Antitoxin
IHV77_RS10015 2087382..2087741 - 360 WP_194811814.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHV77_RS10020 2087822..2088535 + 714 WP_194811815.1 phage minor tail protein L -
IHV77_RS10025 2089393..2090073 + 681 WP_194811816.1 KilA-N domain-containing protein -
IHV77_RS10030 2090199..2090720 + 522 WP_194811817.1 phage antirepressor N-terminal domain-containing protein -
IHV77_RS10035 2090761..2091507 + 747 WP_194811818.1 C40 family peptidase -
IHV77_RS10040 2091450..2092115 + 666 WP_194811819.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2046900..2103885 56985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-83)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 8.0326

>T177570 WP_194811814.1 NZ_CP063056:c2087741-2087382 [Rodentibacter sp. DSM 111151]
MTIEKEWVVIATDRFIAWVNEQDESTRESVLSTLNMLRLYGHHLSRPYADTIKGSKYSNMKELRIQHKGKPLRAFFAFDP
LRQAIVLCAGDKSNDKKFYERMLRIADDEFSAYLQELEK

Download         Length: 360 bp

>T177570 NZ_CP083580:624597-624947 [Bacillus sp. PM8313]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGATATGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATC
CGGACGATTGATAAGCAAAGATTAACGGACAAAATCACTCATCTCGATGATGAAATGATGGAAAAGGTCAATGAAGCCTT
ACAAATCAGTTTGGCACTTATCGATTTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11482.23 Da        Isoelectric Point: 5.9125

>AT177570 WP_194811813.1 NZ_CP063056:c2087380-2087072 [Rodentibacter sp. DSM 111151]
MKKYTTLDELIARQSPESQQRIKEKTEELILEAGLSALREDLELSQKELADALGISQPAVAQIEQRGNELKLSTLKRYIE
TMGGKLSLAVEMPTGHSRIFRI

Download         Length: 309 bp

>AT177570 NZ_CP083580:624311-624592 [Bacillus sp. PM8313]
TTGTCTGAATCCAGCGCTACAACTGAAATTTTGATTCGCTTGCCAGAGGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGTGAACGCAAAAATCGACAAATTC
GAGAATCGATGAGACGCGGTTATATGGAGATGGCAAAGATCAATTTGAACATCTCTTCAGAGGCACAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References