177552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4923091..4923653 Replicon chromosome
Accession NZ_CP063046
Organism Escherichia coli strain KC-Dl-1

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag IL980_RS23625 Protein ID WP_000605675.1
Coordinates 4923375..4923653 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag IL980_RS23620 Protein ID WP_000781370.1
Coordinates 4923091..4923375 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL980_RS23605 4918272..4921319 + 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -
IL980_RS23610 4921332..4922216 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
IL980_RS23615 4922209..4922862 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
IL980_RS23620 4923091..4923375 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
IL980_RS23625 4923375..4923653 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IL980_RS23630 4923839..4924849 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
IL980_RS23635 4924982..4926679 - 1698 WP_000433462.1 malate dehydrogenase -
IL980_RS23640 4926835..4926972 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
IL980_RS23645 4927074..4927289 - 216 WP_000495766.1 biofilm-dependent modulation protein -
IL980_RS23650 4927634..4928065 + 432 WP_021580110.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T177552 WP_000605675.1 NZ_CP063046:c4923653-4923375 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T177552 NZ_CP083530:c4049217-4049110 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT177552 WP_000781370.1 NZ_CP063046:c4923375-4923091 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT177552 NZ_CP083530:4049270-4049331 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References