Detailed information of TA system TA177546

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2491645..2491867
• Replicon: chromosome
• Accession: NZ_CP063046
• Organism: Escherichia coli strain KC-Dl-1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: IL980_RS12075
• Protein ID: WP_000170745.1
• Coordinates: 2491760..2491867 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2491645..2491703 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL980_RS12055	2487086..2487988	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
IL980_RS12060	2487999..2488982	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
IL980_RS12065	2488979..2489983	+	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
IL980_RS12070	2490013..2491284	-	1272	WP_197613153.1	amino acid permease	-
-	2491645..2491703	-	59	-	-	Antitoxin
IL980_RS12075	2491760..2491867	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
IL980_RS12080	2491954..2493633	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
IL980_RS12085	2493630..2493821	-	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
IL980_RS12090	2493818..2495389	-	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
IL980_RS12095	2495662..2495850	+	189	WP_001063314.1	YhjR family protein	-
IL980_RS12100	2495862..2496614	+	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T177546 WP_000170745.1 NZ_CP063046:2491760-2491867 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T177546 NZ_CP083530:2973666-2974064 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT177546 NZ_CP063046:c2491703-2491645 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin