Detailed information of TA system TA177541

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1380787..1381196
• Replicon: chromosome
• Accession: NZ_CP063046
• Organism: Escherichia coli strain KC-Dl-1

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: IL980_RS06685
• Protein ID: WP_001534835.1
• Coordinates: 1380858..1381196 (+)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1380787..1380863 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL980_RS06675	1375975..1377285	+	1311	WP_001534837.1	restriction endonuclease subunit S	-
IL980_RS06680	1377380..1380643	+	3264	WP_001534836.1	type I restriction endonuclease subunit R	-
-	1380787..1380863	-	77	NuclAT_12	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_12	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_12	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_12	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_13	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_13	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_13	-	Antitoxin
-	1380787..1380863	-	77	NuclAT_13	-	Antitoxin
IL980_RS06685	1380858..1381196	+	339	WP_001534835.1	endoribonuclease SymE	Toxin
IL980_RS06690	1381238..1381402	-	165	Protein_1306	DUF1127 domain-containing protein	-
IL980_RS06695	1381580..1381750	+	171	WP_000199350.1	GntR family transcriptional regulator	-
IL980_RS06700	1381880..1382800	-	921	WP_000181193.1	Rpn family recombination-promoting nuclease/putative transposase	-
IL980_RS06705	1382985..1384265	+	1281	WP_001535800.1	DUF445 domain-containing protein	-
IL980_RS06710	1384381..1385532	+	1152	WP_001338076.1	2-hydroxyacyl-CoA dehydratase subunit D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12310.04 Da
• Isoelectric Point: 7.8226

>T177541 WP_001534835.1 NZ_CP063046:1380858-1381196 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYNRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVISNKTPR

Nucleotide

• Length: 339 bp

>T177541 NZ_CP083530:c1612049-1611942 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT177541 NZ_CP063046:c1380863-1380787 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin