Detailed information of TA system TA177538

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1253052..1253310
• Replicon: chromosome
• Accession: NZ_CP063046
• Organism: Escherichia coli strain KC-Dl-1

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: IL980_RS05980
• Protein ID: WP_000809168.1
• Coordinates: 1253158..1253310 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1253052..1253109 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL980_RS05965	1248881..1250140	-	1260	WP_000494928.1	hypothetical protein	-
IL980_RS05970	1250269..1251762	-	1494	WP_001468392.1	sulfatase-like hydrolase/transferase	-
IL980_RS05975	1251782..1252543	-	762	WP_001274832.1	hypothetical protein	-
-	1253052..1253109	-	58	-	-	Antitoxin
IL980_RS05980	1253158..1253310	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
IL980_RS05985	1253415..1254545	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
IL980_RS05990	1254634..1256550	-	1917	WP_000516135.1	molecular chaperone DnaK	-
IL980_RS05995	1256923..1257327	+	405	WP_000843687.1	DUF2541 family protein	-
IL980_RS06000	1257353..1258066	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T177538 WP_000809168.1 NZ_CP063046:1253158-1253310 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T177538 NZ_CP083530:1202890-1203354 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT177538 NZ_CP063046:c1253109-1253052 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin