Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 360117..360763 Replicon chromosome
Accession NZ_CP063019
Organism Klebsiella pneumoniae strain CriePir75

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag GJJ10_RS01665 Protein ID WP_004174016.1
Coordinates 360117..360464 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag GJJ10_RS01670 Protein ID WP_019725405.1
Coordinates 360464..360763 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ10_RS01655 356043..357476 + 1434 WP_002920564.1 glycogen synthase GlgA -
GJJ10_RS01660 357494..359941 + 2448 WP_002920561.1 glycogen phosphorylase -
GJJ10_RS01665 360117..360464 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJJ10_RS01670 360464..360763 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
GJJ10_RS01675 360826..362334 - 1509 WP_019704656.1 glycerol-3-phosphate dehydrogenase -
GJJ10_RS01680 362539..362868 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
GJJ10_RS01685 362919..363749 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
GJJ10_RS01690 363799..364557 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T177500 WP_004174016.1 NZ_CP063019:360117-360464 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T177500 NZ_CP083503:c3102060-3101953 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT177500 WP_019725405.1 NZ_CP063019:360464-360763 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT177500 NZ_CP083503:3102108-3102174 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References