Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3775118..3775715 Replicon chromosome
Accession NZ_CP062997
Organism Klebsiella pneumoniae strain CriePir197

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag GJJ12_RS18620 Protein ID WP_004893639.1
Coordinates 3775398..3775715 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag GJJ12_RS18615 Protein ID WP_004142561.1
Coordinates 3775118..3775405 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ12_RS18585 3771198..3771446 + 249 WP_002893037.1 DUF1158 domain-containing protein -
GJJ12_RS18590 3771464..3771805 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
GJJ12_RS18595 3771836..3772951 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
GJJ12_RS18600 3773131..3773712 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
GJJ12_RS18605 3773712..3774080 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
GJJ12_RS18610 3774200..3774853 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
GJJ12_RS18615 3775118..3775405 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
GJJ12_RS18620 3775398..3775715 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJJ12_RS18625 3775900..3776943 - 1044 WP_009308098.1 DUF2157 domain-containing protein -
GJJ12_RS18630 3777609..3778475 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
GJJ12_RS18635 3778584..3780011 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T177434 WP_004893639.1 NZ_CP062997:c3775715-3775398 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T177434 NZ_CP083492:1436895-1437002 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT177434 WP_004142561.1 NZ_CP062997:c3775405-3775118 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT177434 NZ_CP083492:c1436848-1436782 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References