Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355041..355687 Replicon chromosome
Accession NZ_CP062997
Organism Klebsiella pneumoniae strain CriePir197

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag GJJ12_RS01640 Protein ID WP_004174016.1
Coordinates 355041..355388 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag GJJ12_RS01645 Protein ID WP_008806992.1
Coordinates 355388..355687 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ12_RS01630 350967..352400 + 1434 WP_002920564.1 glycogen synthase GlgA -
GJJ12_RS01635 352418..354865 + 2448 WP_002920561.1 glycogen phosphorylase -
GJJ12_RS01640 355041..355388 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJJ12_RS01645 355388..355687 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
GJJ12_RS01650 355750..357258 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
GJJ12_RS01655 357463..357792 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
GJJ12_RS01660 357843..358673 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
GJJ12_RS01665 358723..359481 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T177421 WP_004174016.1 NZ_CP062997:355041-355388 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T177421 NZ_CP083484:42356-42505 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT177421 WP_008806992.1 NZ_CP062997:355388-355687 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT177421 NZ_CP083484:c42311-42252 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References