Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1514464..1514971 Replicon chromosome
Accession NZ_CP062948
Organism Bifidobacterium lemurum strain DSM 28807

Toxin (Protein)


Gene name HigB2 Uniprot ID A0A261FRT0
Locus tag BL8807_RS05630 Protein ID WP_072724644.1
Coordinates 1514774..1514971 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID A0A261FRS8
Locus tag BL8807_RS05625 Protein ID WP_072724643.1
Coordinates 1514464..1514772 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL8807_RS05610 1509633..1509947 + 315 WP_003828150.1 DUF2469 domain-containing protein -
BL8807_RS05615 1510137..1511747 + 1611 WP_072724639.1 NAD(P)/FAD-dependent oxidoreductase -
BL8807_RS05620 1512060..1514087 + 2028 WP_072724641.1 transcription termination factor Rho -
BL8807_RS05625 1514464..1514772 - 309 WP_072724643.1 helix-turn-helix transcriptional regulator Antitoxin
BL8807_RS05630 1514774..1514971 - 198 WP_072724644.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BL8807_RS05635 1515157..1516578 + 1422 WP_072724645.1 glycoside hydrolase family 32 protein -
BL8807_RS05640 1516665..1517930 + 1266 WP_072724646.1 MFS transporter -
BL8807_RS05645 1518004..1519020 + 1017 WP_072724648.1 LacI family DNA-binding transcriptional regulator -
BL8807_RS05650 1519139..1519528 + 390 WP_072724650.1 chorismate mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-53)

Antitoxin

HigA2-like, helix-turn-helix domain

(25-91)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7816.00 Da        Isoelectric Point: 10.2224

>T177352 WP_072724644.1 NZ_CP062948:c1514971-1514774 [Bifidobacterium lemurum]
MKELRPGSVGRSEIRILFVFDPKRQAIMLVGGDKQRRWNKWYKTAIEQAEARYLAWLEEQYSKEN

Download         Length: 198 bp

>T177352 NZ_CP083448:c3384183-3382864 [Pantoea eucrina]
ATGGCTGAACTGGATGTCTACATGAATGGCTATAAGGTGGGTGTTTTTAGCCGTGCCGGGACCGGTGCTCATGCATTTCA
ATATGCTGAGGCCTGGCTTAATCAGACCGGCAGCCGTCCTGTATCACTTTCCATGCCCTTGCGGCGACAGCCTTATCAGG
GCAATGAGGTTTATAACTTCTTCGATAATCTATTGCCAGATAACCCGGAGATCAGAGGCCGAATCCTGGCCCGCTATAAC
GCAGACTCAACCCAGCCCTTCGACCTTTTGGCACGAATCGGTGCCGATACTGTTGGCGCGCTACAACTGCTACCTAAAGA
TGCCGCGCCGGGCGACATTCGCACCATCGACTACAAAGCATTGTCTGACCGGGATCTGGCCAAAATACTCACAGGCTATA
AAGCTGGCGCGCCCCTGGGCATGATTGAAGAAATTGACGACTTTCGCATATCGCTGGCAGGCGCACAGGAGAAAACTGCC
TTGCTGTTCAGCAATGATTGCTGGTGCCAGCCCAGAGGAACCTCGCCTACAACCCATATTCTCAAATTGCCTATCGGCAA
GATAGAGAGCCACTCATACAGTCTCGACTTGTCAGACAGCGTCGAAAACGAATTTCTCTGCACGCAACTGGCAAAAGAGT
TCGGTTTACCGGTCCCTGATTGCTTTATATTGCATATCAATGATATCAAAGCATTGGCTGTGAAACGGTTTGACCGCCGG
TATGCCTCGGATGGTAGCTGGATAATGCGGCTGCCCCAGGAAGATTTTTGTCAGGTGTTAAATGTTCCTTCAGCACGGAA
ATATGAAAATCAGGGCGGCCCTGGCATAGGCGATATAATGCAAACTCTGCTGGGTTCAGCCAACGCAGAGCAGGATCGTT
ATCACTTTATGAAGGCGCAAGTATTATTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAAAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACTCCTTTTTACGACATCTTGTCTGTCTATCCAGTGTTTGGCGGCCGGGGCCTCAA
TCGAAGAGACGCCAGGCTCGCTATGGGCCTGACAAGCAGCAAGGGGAAAAAATACGCCATTGAGCAGATATTCCCGCGCC
ATTTTTTCCAAACGGCGAAAGCTGTGGGGTTTGAGCGTTCTGTTATGGAAGAGATCCTGACAGAACTGGCTAACTCTGTT
GATGTTGTTATTGAGCGTGTGACCCGGCAATTGCCGGCTGGCTTTCCCGATGCCAACAGCAGCGCCATTCTGGAAGGCCT
GAAAGCCCGTTCAGCCAGACTGATAGCGGGCTGGGAATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11325.05 Da        Isoelectric Point: 8.4754

>AT177352 WP_072724643.1 NZ_CP062948:c1514772-1514464 [Bifidobacterium lemurum]
MTYTIEDFARDHNTDPTKVEAAKARMLEEMRIYELKEARKAQALTQKQLAKQMGVSQKRVSIIESGDVDHVMVSTLKKYL
NGIGGSLSITAKLPSGETLELA

Download         Length: 309 bp

>AT177352 NZ_CP083448:c3384434-3384183 [Pantoea eucrina]
ATGAAGATTATTAATGTCAGCCAGCTCAGCGCTCACCTGCGAGATGTTCGTCTGTCAAAAAAACTGTCTCAGGGAAAAGT
GGCCAGCAAGGTAGGGATTCGCCAGGACACCGTATCCAGCTTTGAACTCCAGCCAGGCACCAGCAGGCTGGAAACTTTTT
TCAGGATATTGTCAGCACTGGAGCTGGAGCTGGAGGTGAAACCCAAAGGCAGCGATACCCAAAGCTCTGAAGGCTGGAAA
GAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A261FRT0

Antitoxin

Source ID Structure
AlphaFold DB A0A261FRS8

References