Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2571238..2571871 Replicon chromosome
Accession NZ_CP062946
Organism Thalassotalea sp. LPB0316

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP316_RS11470 Protein ID WP_193021300.1
Coordinates 2571238..2571570 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP316_RS11475 Protein ID WP_193021301.1
Coordinates 2571557..2571871 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP316_RS11440 2566797..2567384 + 588 WP_193021295.1 thymidine kinase -
LP316_RS11445 2567893..2568480 - 588 WP_193021296.1 hypothetical protein -
LP316_RS11450 2568407..2568589 + 183 Protein_2211 transposase -
LP316_RS11455 2568675..2569367 - 693 WP_193021297.1 hypothetical protein -
LP316_RS11460 2569387..2570076 - 690 WP_193021298.1 hypothetical protein -
LP316_RS11465 2570537..2571148 - 612 WP_193021299.1 tyrosine-type recombinase/integrase -
LP316_RS11470 2571238..2571570 + 333 WP_193021300.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP316_RS11475 2571557..2571871 + 315 WP_193021301.1 DNA-binding transcriptional regulator Antitoxin
LP316_RS11480 2572153..2572407 + 255 WP_193021302.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LP316_RS11485 2572400..2572663 + 264 WP_193021303.1 Txe/YoeB family addiction module toxin -
LP316_RS11490 2572869..2574185 - 1317 WP_193021304.1 thymidine phosphorylase -
LP316_RS11495 2574195..2574590 - 396 WP_193021305.1 cytidine deaminase -
LP316_RS11500 2574824..2576569 - 1746 WP_193021306.1 DUF3466 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(44-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12886.77 Da        Isoelectric Point: 9.7103

>T177347 WP_193021300.1 NZ_CP062946:2571238-2571570 [Thalassotalea sp. LPB0316]
MEAIFIESSIFEKHRQSYMSDDEYRAFQQELLINPLQGDVIQGTGGLRKIRVAAKGKGKRGGARIIYYYFVQYRRFYLLT
VYAKNEMADLTASQKAQLKDFMEVWKNEQS

Download         Length: 333 bp

>T177347 NZ_CP083445:3437935-3438345 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11658.10 Da        Isoelectric Point: 6.9897

>AT177347 WP_193021301.1 NZ_CP062946:2571557-2571871 [Thalassotalea sp. LPB0316]
MSNRDLFSELTTALNEAKAHSEGKLTLKTHEVKEASNLEISPQEIVSIREQYNMSRGVFARYLHTSARTLENWEQGRSAP
NGQAVTLLKLVQTHPETLSHIASL

Download         Length: 315 bp

>AT177347 NZ_CP083445:3437688-3437954 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References