Detailed information of TA system TA177337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 366690..367210
• Replicon: chromosome
• Accession: NZ_CP062945
• Organism: Bifidobacterium longum subsp. longum strain JCM 11340

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: BL1134_RS01680
• Protein ID: WP_117701510.1
• Coordinates: 366956..367210 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: BL1134_RS01675
• Protein ID: WP_117701509.1
• Coordinates: 366690..366956 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL1134_RS01655	363937..364254	+	318	WP_131207568.1	HigA family addiction module antidote protein	-
BL1134_RS01660	364522..365376	+	855	WP_193027419.1	hypothetical protein	-
BL1134_RS01665	365753..366118	-	366	WP_193027342.1	hypothetical protein	-
BL1134_RS01670	366141..366521	-	381	WP_193027343.1	hypothetical protein	-
BL1134_RS01675	366690..366956	+	267	WP_117701509.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BL1134_RS01680	366956..367210	+	255	WP_117701510.1	Txe/YoeB family addiction module toxin	Toxin
BL1134_RS01685	367314..368303	-	990	WP_193027345.1	hypothetical protein	-
BL1134_RS01690	368503..368770	-	268	Protein_329	hypothetical protein	-
BL1134_RS01695	368781..369329	-	549	WP_193027347.1	hypothetical protein	-
BL1134_RS01700	369568..369813	+	246	WP_007053507.1	hypothetical protein	-
BL1134_RS01705	369902..371578	+	1677	WP_100969855.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	364522..421719	57197

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9863.31 Da
• Isoelectric Point: 8.2604

>T177337 WP_117701510.1 NZ_CP062945:366956-367210 [Bifidobacterium longum subsp. longum]
MLLCWTDDAWADYLYWQSQDRKTLKRINALIRDMQRTPFEGIGKPEPLRCGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Nucleotide

• Length: 255 bp

>T177337 NZ_CP083444:c1049681-1049358 [Bartonella taylorii]
ATGCGTGGTTCTCTCGTAACAATAGCTATACAAGGCGATTTTGGTAAACCAAGACCCGCATTGATCATTCAAGCTAATCA
ATTTAGTGAACATACCAGCATGACGGTTTTACCAATTACAAGTACACTTGTTGATGCGCCATTACTCCGTATTACTATCC
AACCAGACAGCAAAAATGGTTTACAAAAACCTTCGCAAGTGATGATTGATAAGATTATGACGGTAAGGTGTGAAAAAGTT
AGTCCAGCTTTCGGTTCCATTCGAGCAGACAAAATGTTAGAAATTGAACGCTGTCTGGCTGTATTTTTAGGAATAGTAAA
ATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9911.09 Da
• Isoelectric Point: 4.3417

>AT177337 WP_117701509.1 NZ_CP062945:366690-366956 [Bifidobacterium longum subsp. longum]
MTQAVAYSNFRANLKTYMRRVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVTRGMAQVRQGQTMA
RDLVEAGA

Nucleotide

• Length: 267 bp

>AT177337 NZ_CP083444:c1049905-1049681 [Bartonella taylorii]
ATGGGTACAATGCACGTTAATGAACGTGTTCAAAAACATCGCAACGCACAAAGGAAAGCGGGATTGCGCTTAATGCAAAT
TTGGGTACCAGATACACGCCAGCCAAATTTTGTAGAAGAATGCCGCCGTCAGTGTCGCTTAGTGGTAAAAATGGATAAAA
AAGATGCATCTATGCAGTTGTTTATGGATCAATCTTTAATGGATGTTGATGGCTGGACAGACTGA