Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 6538..7123 Replicon plasmid unnamednovel_1
Accession NZ_CP062922
Organism Acinetobacter baumannii strain Res13-Abat-PEA21-P4-01-A

Toxin (Protein)


Gene name higB Uniprot ID A0A3F3L0I7
Locus tag IMO23_RS19215 Protein ID WP_039253786.1
Coordinates 6538..6858 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7S8WHM6
Locus tag IMO23_RS19220 Protein ID WP_062034273.1
Coordinates 6851..7123 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMO23_RS19200 3884..4813 + 930 WP_086222692.1 replication initiation protein RepM -
IMO23_RS19205 4901..5446 + 546 WP_195707829.1 plasmid replication DNA-binding protein -
IMO23_RS19210 5756..6355 + 600 WP_180185718.1 HEAT repeat domain-containing protein -
IMO23_RS19215 6538..6858 + 321 WP_039253786.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMO23_RS19220 6851..7123 + 273 WP_062034273.1 helix-turn-helix domain-containing protein Antitoxin
IMO23_RS19225 7218..7682 - 465 WP_025464221.1 hypothetical protein -
IMO23_RS19230 7676..8410 - 735 WP_005804942.1 hypothetical protein -
IMO23_RS19235 8997..9554 - 558 WP_039254943.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14288 14288


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12207.00 Da        Isoelectric Point: 7.9849

>T177325 WP_039253786.1 NZ_CP062922:6538-6858 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILRQLVKEQFHG

Download         Length: 321 bp

>T177325 NZ_CP083443:2151699-2151801 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10148.62 Da        Isoelectric Point: 9.8619

>AT177325 WP_062034273.1 NZ_CP062922:6851-7123 [Acinetobacter baumannii]
MDNNLFDNLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT177325 NZ_CP083443:c2151808-2151663 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3F3L0I7

Antitoxin

Source ID Structure
AlphaFold DB A0A7S8WHM6

References