Detailed information of TA system TA177324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 17534..18192
• Replicon: plasmid unnamed1836
• Accession: NZ_CP062921
• Organism: Acinetobacter baumannii strain Res13-Abat-PEA21-P4-01-A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IMO23_RS18905
• Protein ID: WP_000312250.1
• Coordinates: 17833..18192 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IMO23_RS18900
• Protein ID: WP_001096429.1
• Coordinates: 17534..17833 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMO23_RS18870	12949..14205	+	1257	WP_072689898.1	ParB/RepB/Spo0J family partition protein	-
IMO23_RS18875	14341..15570	+	1230	WP_033854393.1	hypothetical protein	-
IMO23_RS18880	15585..15818	+	234	WP_033854394.1	hypothetical protein	-
IMO23_RS18885	15859..16116	+	258	WP_195707824.1	hypothetical protein	-
IMO23_RS18890	16121..16693	+	573	WP_000443897.1	hypothetical protein	-
IMO23_RS18895	16669..16848	+	180	WP_033854395.1	hypothetical protein	-
IMO23_RS18900	17534..17833	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
IMO23_RS18905	17833..18192	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IMO23_RS18910	18393..18959	+	567	WP_000710385.1	hypothetical protein	-
IMO23_RS18915	19008..19190	+	183	WP_000373385.1	hypothetical protein	-
IMO23_RS18920	19257..19955	+	699	WP_138152779.1	hypothetical protein	-
IMO23_RS18925	20094..20477	+	384	WP_000654348.1	hypothetical protein	-
IMO23_RS18930	20544..21302	+	759	WP_195707825.1	hypothetical protein	-
IMO23_RS18935	21354..21689	+	336	WP_038337724.1	hypothetical protein	-
IMO23_RS18940	21848..22778	+	931	Protein_37	IS5-like element ISAba13 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..72831	72831
	-	flank	IS/Tn	-	-	21848..22306	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T177324 WP_000312250.1 NZ_CP062921:c18192-17833 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T177324 NZ_CP083443:998788-999198 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT177324 WP_001096429.1 NZ_CP062921:c17833-17534 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT177324 NZ_CP083443:998541-998807 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA