Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1828407..1828909 Replicon chromosome
Accession NZ_CP062901
Organism Escherichia coli O152:H23 strain Res13-Lact-ER01-35

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IMP37_RS08675 Protein ID WP_000767829.1
Coordinates 1828655..1828909 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IMP37_RS08670 Protein ID WP_001259255.1
Coordinates 1828407..1828658 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP37_RS08645 1823584..1824651 - 1068 WP_047082052.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
IMP37_RS08650 1824651..1825721 - 1071 WP_000108919.1 histidinol-phosphate transaminase -
IMP37_RS08655 1825718..1827022 - 1305 WP_001676612.1 histidinol dehydrogenase -
IMP37_RS08660 1827028..1827927 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
IMP37_RS08665 1828073..1828123 - 51 WP_001364200.1 his operon leader peptide -
IMP37_RS08670 1828407..1828658 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IMP37_RS08675 1828655..1828909 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IMP37_RS08680 1828992..1829816 + 825 WP_000754758.1 SDR family oxidoreductase -
IMP37_RS08685 1829862..1830791 + 930 WP_000803366.1 LysR family transcriptional regulator -
IMP37_RS08690 1831006..1831068 + 63 WP_010723108.1 membrane protein YoeI -
IMP37_RS08695 1831058..1832416 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IMP37_RS08700 1832595..1833653 + 1059 WP_167791450.1 transport protein YeeE -
IMP37_RS08705 1833667..1833894 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T177227 WP_000767829.1 NZ_CP062901:1828655-1828909 [Escherichia coli O152:H23]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T177227 NZ_CP083351:c165078-164695 [Ensifer adhaerens]
GTGATACTTGCAGACACCTCAATCTGGATTGATCATTTTCGGCATGCCGATGGTGAGTTGCGCAGGATTATTGAAGACGA
TCTTCTCCTCTGCCATCCCGCTGTGATTGGCGAACTGGCACTTGGCAGCCTTCGCGACCGCAGTAACGTCTTGGCCGTCC
TGGCGGCTCAGCGTGAGGCGCTCGTCGCAACCCATGACGAAGTCATGACGATGATTGATCGGCACGCCATTTTCAGCATG
GGCATTGGCTACACAGATGCCCATTTGCTGGCCTCAGTTCTCCTTGATCATCGAGCCACTTTGTGGACCAGAGACAAGCG
GCTGCGGGTAGCCGCTGAAAAGGCAGGGGCTCTGTTGCATTTGGCTGGCAATTCACGGAACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT177227 WP_001259255.1 NZ_CP062901:1828407-1828658 [Escherichia coli O152:H23]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT177227 NZ_CP083351:c165275-165075 [Ensifer adhaerens]
ATGCGGTCGACTATCAACCTCGATGATACTCTCATAGAAAGAGCCAAGTCCCTGACCGGCACGAAGGAAACCTCCGCCTT
GGTTCGGCAGGCGTTAGAGACACTTGTTCGGGTGGAGTCCGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGAATG
CGGAGGCAGCCCCACGCCGCAGGAGCGCAGCAGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References