Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 593385..594184 Replicon chromosome
Accession NZ_CP062901
Organism Escherichia coli O152:H23 strain Res13-Lact-ER01-35

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag IMP37_RS02890 Protein ID WP_000347267.1
Coordinates 593385..593849 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IMP37_RS02895 Protein ID WP_001307405.1
Coordinates 593849..594184 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP37_RS02860 588386..588820 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IMP37_RS02865 588838..589716 - 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IMP37_RS02870 589706..590485 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IMP37_RS02875 590496..590969 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
IMP37_RS02880 590992..592272 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
IMP37_RS02885 592521..593330 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IMP37_RS02890 593385..593849 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IMP37_RS02895 593849..594184 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IMP37_RS02900 594333..595904 - 1572 WP_001273741.1 galactarate dehydratase -
IMP37_RS02905 596279..597613 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IMP37_RS02910 597629..598399 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T177222 WP_000347267.1 NZ_CP062901:c593849-593385 [Escherichia coli O152:H23]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T177222 NZ_CP083350:22504-22908 [Ensifer adhaerens]
GTGATCTCGCACCTTCTCGATACCAACGCTGTCATTGCCTTGATCGGCCGAAAATCGGATAGATTGGTCAGCCGTGTTCT
CCACAGCCCTCAGGGCAGTCTCGGCCTACCCTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAAAAAAGCGCAAAGG
TCCAACACAACCTGGAAACCTTGCGTTTGTTGATGGCGGATTTTTCGATCCTCGATTTTGACCAGAATGACGCCTTTGTC
GCGGGCGAGATCCGGGCGGCCCTTGCCGCTAAGGGGACGCCCATTGGCCCCTATGACGTGCTGATCGCAGGGCAGGCGAA
AGCCCGTGGATTGACCCTCGTCACTAACAATGTCGGCGAGTTCAACCGGGTTGAGAACTTGCATGTGGAGGATTGGTCGG
TGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT177222 WP_001307405.1 NZ_CP062901:c594184-593849 [Escherichia coli O152:H23]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT177222 NZ_CP083350:22247-22507 [Ensifer adhaerens]
ATGCCCCATCTTGCACGCGTATTCCAGTCCGGAAACTCGCAGGCCGTCCGCCTGCCGAAGGAATTCCGCTTCAACGTCGA
GCGCGTGGAGATCACGCAGGAGGGCGATGCTCTCATTCTCCGTCCGCATGTCGAGGCGGGCGAGCCGTGGTCGTCGCTGA
AGGCAGCGCTGGCCCGCGGCATGACTGACGACTTCATGGAGAGCGGGCGCGAGCAGCCGGAACAGCAGGATCGACCGGAA
CTTGACGCGGTGTTTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References